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铝作为一种神经毒素,其风险有多大?

What is the risk of aluminium as a neurotoxin?

机构信息

The Birchall Centre, Lennard-Jones Laboratories, Keele University, Staffordshire, UK.

出版信息

Expert Rev Neurother. 2014 Jun;14(6):589-91. doi: 10.1586/14737175.2014.915745. Epub 2014 Apr 30.

Abstract

Aluminium is neurotoxic. Its free ion, Al(3+) (aq), is highly biologically reactive and uniquely equipped to do damage to essential cellular (neuronal) biochemistry. This unequivocal fact must be the starting point in examining the risk posed by aluminium as a neurotoxin in humans. Aluminium is present in the human brain and it accumulates with age. The most recent research demonstrates that a significant proportion of individuals older than 70 years of age have a potentially pathological accumulation of aluminium somewhere in their brain. What are the symptoms of chronic aluminium intoxication in humans? What if neurodegenerative diseases such as Alzheimer's disease are the manifestation of the risk of aluminium as a neurotoxin? How might such an (outrageous) hypothesis be tested?

摘要

铝具有神经毒性。其游离离子 Al(3+)(aq)具有高度的生物反应性,能够特异性地对关键的细胞(神经元)生物化学造成损害。这一明确的事实必须成为研究铝作为人类神经毒素所带来的风险的起点。铝存在于人类大脑中,并随着年龄的增长而积累。最新的研究表明,相当一部分 70 岁以上的人其大脑的某个部位存在潜在病理性的铝积累。那么,人类慢性铝中毒的症状是什么?如果像阿尔茨海默病这样的神经退行性疾病是铝作为神经毒素的风险的表现,又会怎样呢?这样一个(令人震惊)的假设该如何验证?

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