Bruggink Cees, Jensen Detlef
InIon Chromatography Breda AT The Netherlands.
Thermo Fisher Scientific GmbH Dreieich Germany.
Anal Sci Adv. 2020 Dec 4;2(3-4):238-249. doi: 10.1002/ansa.202000120. eCollection 2021 Apr.
The demand for analyzing low molecular weight polar and ionic components in body fluids, pharmaceutical formulations, food, environmental samples, and drinking water is increasing. Ion chromatography (IC) offers significant advantages over RPLC and HILIC due to a complementary chromatographic selectivity, a different retention mechanism, and a high tolerance toward complex matrices. A continuously regenerated membrane desalter simplifies the combination of IC-applications with MS- or MS/MS-detection, improving the sensitivity and specificity. Analytical workflows are streamlined, providing higher sample throughput. Combining IC with ICP-MS simplifies the speciation analysis of inorganic and organic polar components. The knowledge about the distribution of an element among chemical species in a sample is essential due to significantly different toxicological or environmental properties. This annual review evaluates the literature published from late 2019 until November 2020.
对体液、药物制剂、食品、环境样品和饮用水中的低分子量极性和离子成分进行分析的需求日益增加。离子色谱（IC）由于具有互补的色谱选择性、不同的保留机制以及对复杂基质的高耐受性，与反相液相色谱（RPLC）和亲水作用色谱（HILIC）相比具有显著优势。连续再生膜脱盐器简化了IC应用与质谱（MS）或串联质谱（MS/MS）检测的结合，提高了灵敏度和特异性。分析工作流程得到简化，提供了更高的样品通量。将IC与电感耦合等离子体质谱（ICP-MS）相结合，简化了无机和有机极性成分的形态分析。由于样品中元素在化学形态间的分布具有显著不同的毒理学或环境特性，了解这些分布情况至关重要。本年度综述评估了2019年末至2020年11月发表的文献。
