Epigenetics Program, Institute of Regenerative Medicine, Department of Cell and Developmental Biology, University of Pennsylvania Perelman School of Medicine, Smilow Center for Translational Research, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA.
Dev Cell. 2014 Apr 28;29(2):132-4. doi: 10.1016/j.devcel.2014.04.019.
Transcription is silenced during mitosis and reactivated at mitotic exit. The dynamics and identities of "bookmarking" transcription factors and chromatin marks that mediate reactivation often recapitulate those observed during cell identity establishment in development. Thus, features of postmitotic gene reactivation can provide insights into mechanisms of developmental cell fate establishment.
转录在有丝分裂期间被沉默，并在有丝分裂退出时被重新激活。介导重新激活的“标记”转录因子和染色质标记的动态和身份通常再现了在发育过程中细胞身份建立期间观察到的那些。因此，有丝分裂后基因重新激活的特征可以为发育细胞命运建立的机制提供见解。
