Wang X Q, Gao P Y, Lin Y Z, Chen C M
Institute of Nutrition and Food Hygiene, Chinese Academy of Preventive Medicine, Beijing.
Biomed Environ Sci. 1988 Aug;1(2):138-51.
Organochlorine pesticides in cerumen were used as a biological marker to monitor the exposure of organochlorine pesticides in the human body. The amount of sample used was about 10 mg. The order of magnitude of HCH (hexachlorocyclohexane) isomer content in cerumen was beta greater than alpha greater than gamma greater than delta; for DDT, the order was p,p'-DDE greater than p,p'-DDT. There was little o,p'-DDT and p,p'-DDD. The contents of beta-HCH and p,p'-DDE in cerumen were highly significantly correlated with those in adipose tissue of the same individuals. Approximately 3800 cerumen samples collected from 35- to 54-year-old healthy adults in the general populations of 35 counties were analyzed for HCH and DDT. The accumulation levels of beta-HCH had a geographical character with obvious gradient differences, and the levels were higher in males than in females. The accumulation levels of beta-HCH in the populations studied were highly significantly correlated with the mortality rates from liver cancer, colon/rectum cancer, and lung cancer in males as well as colon/rectum cancer in females (P less than 0.01), suggesting that the effect of HCH on the above cancers should be studied further.
耳垢中的有机氯农药被用作一种生物标志物，以监测人体中有机氯农药的暴露情况。所用样品量约为10毫克。耳垢中六氯环己烷（HCH）异构体含量的数量级顺序为β＞α＞γ＞δ；对于滴滴涕（DDT），顺序为p,p'-DDE＞p,p'-DDT。o,p'-DDT和p,p'-DDD含量很少。耳垢中β-HCH和p,p'-DDE的含量与同一人群脂肪组织中的含量高度显著相关。对从35个县的普通人群中35至54岁健康成年人收集的约3800份耳垢样品进行了HCH和DDT分析。β-HCH的累积水平具有地理特征，存在明显的梯度差异，且男性水平高于女性。所研究人群中β-HCH的累积水平与男性肝癌、结肠癌/直肠癌和肺癌以及女性结肠癌/直肠癌的死亡率高度显著相关（P＜0.01），表明应进一步研究HCH对上述癌症的影响。
