Cohen S R, Brooks B R, Herndon R M, McKhann G M
Ann Neurol. 1980 Jul;8(1):25-31. doi: 10.1002/ana.410080104.
We have developed a radioimmunoassay to measure a specific neurological component, the basic protein of myelin, and have used this test for assessing this component in spinal fluid. The levels of basic protein in spinal fluid correlate closely with the clinical activity of multiple sclerosis; therefore the test can be used for objective evaluation of disease activity in patients with that disorder. Moreover, it is a useful adjunct in the diagnosis of multiple sclerosis and evaluation of potential therapy. In addition, the test is helpful in diagnosing other diseases in which acute breakdown of myelin occurs, especially leukoencephalopathy resulting from irradiation and chemotherapy for treatment of leukemia in children.
我们开发了一种放射免疫测定法来测量一种特定的神经学成分，即髓磷脂碱性蛋白，并已使用该测试来评估脑脊液中的这种成分。脑脊液中碱性蛋白的水平与多发性硬化症的临床活动密切相关；因此，该测试可用于客观评估该疾病患者的疾病活动。此外，它在多发性硬化症的诊断和潜在治疗评估中是一种有用的辅助手段。此外，该测试有助于诊断其他发生髓磷脂急性分解的疾病，特别是儿童白血病放疗和化疗引起的白质脑病。
