Dayan Franck E, Duke Stephen O
United States Department of Agriculture, Agricultural Research Service, Natural Products Utilization Research Unit, University, Mississippi 38677.
United States Department of Agriculture, Agricultural Research Service, Natural Products Utilization Research Unit, University, Mississippi 38677
Plant Physiol. 2014 Nov;166(3):1090-105. doi: 10.1104/pp.114.239061. Epub 2014 Apr 30.
Herbicides with new modes of action (MOAs) are badly needed due to the rapidly evolving resistance to commercial herbicides, but a new MOA has not been introduced in over 20 years. The greatest pest management challenge for organic agriculture is the lack of effective natural product herbicides. The structural diversity and evolved biological activity of natural phytotoxins offer opportunities for the development of both directly used natural compounds and synthetic herbicides with new target sites based on the structures of natural phytotoxins. Natural phytotoxins are also a source for the discovery of new herbicide target sites that can serve as the focus of traditional herbicide discovery efforts. There are many examples of strong natural phytotoxins with MOAs other than those used by commercial herbicides, which indicates that there are molecular targets of herbicides that can be added to the current repertoire of commercial herbicide MOAs.
由于对商业除草剂的抗性迅速演变，急需具有新作用模式（MOA）的除草剂，但20多年来一直没有引入新的MOA。有机农业面临的最大害虫管理挑战是缺乏有效的天然产物除草剂。天然植物毒素的结构多样性和进化的生物活性为直接使用天然化合物以及基于天然植物毒素结构开发具有新靶标的合成除草剂提供了机会。天然植物毒素也是发现新除草剂靶标的来源，这些靶标可作为传统除草剂发现工作的重点。有许多天然植物毒素具有不同于商业除草剂所用作用模式的例子，这表明存在可添加到当前商业除草剂作用模式库中的除草剂分子靶标。
