Ghosh Arun K, Chen Zhi-Hua
Department of Chemistry and Department of Medicinal Chemistry, Purdue University, West Lafayette, IN 47907, USA.
Org Biomol Chem. 2014 Jun 14;12(22):3567-71. doi: 10.1039/c4ob00511b. Epub 2014 May 1.
Efficient intramolecular N/O-nucleophilic cyclization of 2-aryl indoles has been developed to afford the corresponding 2-aza-3-oxaindolines and 3-indolinones in 80-95% yield. The methods provided convenient access to fused imidazo[1,2-c]oxazolidinone, oxazolidine, or tetrahydro-1,3-oxazine cores under mild conditions.
已开发出2-芳基吲哚的高效分子内N/O-亲核环化反应，以80-95%的产率得到相应的2-氮杂-3-氧代吲哚啉和3-吲哚酮。这些方法在温和条件下提供了便捷的途径来合成稠合的咪唑并[1,2-c]恶唑烷酮、恶唑烷或四氢-1,3-恶嗪核心结构。
