Natural Products Discovery Group, Stephenson Life Sciences Research Center, 101 Stephenson Parkway, University of Oklahoma, Norman, Oklahoma 73019-5251, USA.
Org Lett. 2013 Aug 16;15(16):4186-9. doi: 10.1021/ol401891z. Epub 2013 Aug 7.
Four metabolites, teraspiridoles A-D (2-5), formed from the merger of a diterpene and modified indole scaffold were obtained from an Aspergillus terreus isolate. The structures and absolute configurations of these natural products were established using NMR, mass spectrometry, Marfey's method, VCD, and ECD data. Teraspiridole B (3) exhibited weak inhibition of planaria regeneration/survival.
四种代谢产物，teraspiridoles A-D（2-5），是从一株土曲霉分离物中得到的，由二萜和修饰吲哚支架融合而成。这些天然产物的结构和绝对构型是通过 NMR、质谱、Marfey 法、VCD 和 ECD 数据确定的。Teraspiridole B（3）表现出对扁形动物再生/存活的弱抑制作用。
