Kusama Taishi, Tanaka Naonobu, Takahashi-Nakaguchi Azusa, Gonoi Tohru, Fromont Jane, Kobayashi Jun'ichi
Graduate School of Pharmaceutical Sciences, Hokkaido University.
Chem Pharm Bull (Tokyo). 2014;62(5):499-503. doi: 10.1248/cpb.c14-00077.
Five new bromopyrrole alkaloids, 2-bromokeramadine (1), 2-bromo-9,10-dihydrokeramadine (2), tauroacidins C (3) and D (4), and mukanadin G (5), were isolated from an Okinawan marine sponge Agelas sp. The structures of 1-5 were elucidated on the basis of spectroscopic data and conformational analysis. Mukanadin G (5) has a tricyclic skeleton consisting of a fused tetrahydrobenzaminoimidazole and 2,5-dioxopyrrolidine moieties. Antimicrobial activities of 1-3, and 5 as well as three related known bromopyrrole alkaloids, keramadine (6), tauroacidin A (7), and taurodispacamide A (8) were evaluated.
从冲绳海洋海绵Agelas sp.中分离出了五种新的溴吡咯生物碱，即2-溴卡拉马定（1）、2-溴-9,10-二氢卡拉马定（2）、牛磺酸菌素C（3）和D（4）以及木卡纳丁G（5）。通过光谱数据和构象分析阐明了1-5的结构。木卡纳丁G（5）具有由稠合的四氢苯并氨基咪唑和2,5-二氧代吡咯烷部分组成的三环骨架。评估了1-3、5以及三种相关的已知溴吡咯生物碱卡拉马定（6）、牛磺酸菌素A（7）和牛磺酸二肽酰胺A（8）的抗菌活性。
