Tsai Robert Y L, Pederson Thoru
Center for Cancer and Stem Cell Biology, Institute of Biosciences and Technology, Texas A&M Health Science Center, Houston, Texas, USA; and
Program in Cell and Developmental Dynamics, Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, USA
FASEB J. 2014 Aug;28(8):3290-6. doi: 10.1096/fj.14-254680. Epub 2014 Apr 30.
Long known as the center of ribosome synthesis, the nucleolus is connected to cell cycle regulation in more subtle ways. One is a surveillance system that reacts promptly when rRNA synthesis or processing is impaired, halting cell cycle progression. Conversely, the nucleolus also acts as a first-responder to growth-related stress signals. Here we review emerging concepts on how these "infraribosomal" links between the nucleolus and cell cycle progression operate in both forward and reverse gears. We offer perspectives on how new cancer therapeutic designs that target this infraribosomal mode of cell growth control may shape future clinical progress.
长久以来，核仁一直被认为是核糖体合成的中心，它以更为微妙的方式与细胞周期调控相关联。其中一种方式是监控系统，当rRNA合成或加工受到损害时，该系统会迅速做出反应，使细胞周期进程停止。相反，核仁也会对与生长相关的应激信号做出第一反应。在此，我们回顾关于核仁与细胞周期进程之间这些“核糖体下”联系如何正向和反向发挥作用的新观点。我们就靶向这种核糖体下细胞生长控制模式的新型癌症治疗设计如何塑造未来临床进展提供观点。
