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雷贝拉唑联合质子泵抑制剂对胃食管反流病大鼠模型中紧密连接蛋白表达的相加作用。

Additive Effects of Rebamipide Plus Proton Pump Inhibitors on the Expression of Tight Junction Proteins in a Rat Model of Gastro-Esophageal Reflux Disease.

机构信息

Division of Gastroenterology, Department of Internal Medicine, Incheon St. Mary's Hospital, The Catholic University of Korea College of Medicine, Incheon, Korea.

Department of Laboratory Animal Medicine, Konkuk University College of Veterinary Medicine, Seoul, Korea.

出版信息

Gut Liver. 2018 Jan 15;12(1):46-50. doi: 10.5009/gnl17078.

DOI:10.5009/gnl17078
PMID:29069891
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5753683/
Abstract

BACKGROUND/AIMS: The aim of this study was to investigate the effects of rebamipide on tight junction proteins in the esophageal mucosa in a rat model of gastroesophageal reflux disease (GERD).

METHODS

GERD was created in rats by tying the proximal stomach. The rats were divided into a control group, a proton pump inhibitor (PPI) group, and a PPI plus rebamipide (PPI+R) group. Pantoprazole (5 mg/kg) was administered intraperitoneally to the PPI and PPI+R groups. An additional dose of rebamipide (100 mg/kg) was administered orally to the PPI+R group. Mucosal erosions, epithelial thickness, and leukocyte infiltration into the esophageal mucosa were measured in isolated esophagi 14 days after the procedure. A Western blot analysis was conducted to measure the expression of claudin-1, -3, and -4.

RESULTS

The mean surface area of mucosal erosions, epithelial thickness, and leukocyte infiltration were lower in the PPI group and the PPI+R group than in the control group. Western blot analysis revealed that the expression of claudin-3 and -4 was significantly higher in the PPI+R group than in the control group.

CONCLUSIONS

Rebamipide may exert an additive effect in combination with PPI to modify the tight junction proteins of the esophageal mucosa in a rat model of GERD. This treatment might be associated with the relief of GERD symptoms.

摘要

背景/目的：本研究旨在探讨瑞巴派特对胃食管反流病（GERD）大鼠模型食管黏膜紧密连接蛋白的影响。

方法

通过结扎近端胃来建立 GERD 大鼠模型。将大鼠分为对照组、质子泵抑制剂（PPI）组和 PPI+瑞巴派特（PPI+R）组。PPI 和 PPI+R 组大鼠均经腹腔注射泮托拉唑（5mg/kg）。PPI+R 组大鼠另给予瑞巴派特（100mg/kg）口服。术后 14 天，分离食管测量黏膜糜烂、上皮厚度和白细胞浸润入食管黏膜的情况。采用 Western blot 分析测量紧密连接蛋白-1、-3 和-4 的表达。

结果

PPI 组和 PPI+R 组的黏膜糜烂面积、上皮厚度和白细胞浸润的平均面积均低于对照组。Western blot 分析显示，PPI+R 组 claudin-3 和 -4 的表达明显高于对照组。

结论

瑞巴派特与 PPI 联合使用可能对 GERD 大鼠模型的食管黏膜紧密连接蛋白具有附加作用。这种治疗方法可能与 GERD 症状的缓解有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81e1/5753683/aa4b26051ac4/gnl-12-046f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81e1/5753683/b436fff62aca/gnl-12-046f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81e1/5753683/1fa6565ba4b1/gnl-12-046f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81e1/5753683/822664a3ba3d/gnl-12-046f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81e1/5753683/aa4b26051ac4/gnl-12-046f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81e1/5753683/b436fff62aca/gnl-12-046f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81e1/5753683/1fa6565ba4b1/gnl-12-046f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81e1/5753683/822664a3ba3d/gnl-12-046f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81e1/5753683/aa4b26051ac4/gnl-12-046f4.jpg

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本文引用的文献

1
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Auris Nasus Larynx. 2014 Dec;41(6):539-42. doi: 10.1016/j.anl.2014.05.011. Epub 2014 Jun 11.
2
Esophageal barrier function and tight junction expression in healthy subjects and patients with gastroesophageal reflux disease: functionality of esophageal mucosa exposed to bile salt and trypsin in vitro.健康受试者和胃食管反流病患者的食管屏障功能及紧密连接表达：体外暴露于胆盐和胰蛋白酶的食管黏膜功能
Scand J Gastroenterol. 2013 Oct;48(10):1118-26. doi: 10.3109/00365521.2013.828772.
3
Claudins and the modulation of tight junction permeability.
Role of extract as medicinal food on reflux esophagitis in rats.
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Food Sci Nutr. 2021 May 6;9(6):3114-3122. doi: 10.1002/fsn3.2270. eCollection 2021 Jun.
4
Tojapride Reverses Esophageal Epithelial Inflammatory Responses on Reflux Esophagitis Model Rats.托拉唑利逆转反流性食管炎模型大鼠食管上皮炎症反应。
Chin J Integr Med. 2021 Aug;27(8):604-612. doi: 10.1007/s11655-019-3027-5. Epub 2020 Apr 4.
5
Novel Therapies for Gastroesophageal Reflux Disease: Beyond Proton Pump Inhibitors.治疗胃食管反流病的新疗法：质子泵抑制剂之外。
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7
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J Gastroenterol. 2010 May;45(5):478-87. doi: 10.1007/s00535-009-0180-1. Epub 2009 Dec 18.
8
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Gut. 2008 Oct;57(10):1366-74. doi: 10.1136/gut.2007.141804. Epub 2008 Jul 1.
9
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10
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