Rudov Alexander, Balduini Walter, Carloni Silvia, Perrone Serafina, Buonocore Giuseppe, Albertini Maria Cristina
Department of Biomolecular Sciences, University of Urbino, Via Saffi 2, 61029 Urbino, Italy.
Department of Molecular and Developmental Medicine, University of Siena, Viale Bracci, 36, 53100 Siena, Italy.
Oxid Med Cell Longev. 2014;2014:103068. doi: 10.1155/2014/103068. Epub 2014 Mar 18.
Oxidative stress (OS) is known to be strongly involved in a large number of fetal, neonatal, and adult diseases, including placental disorders, leading to pregnancy loss and stillbirths. A growing body of research links OS to preeclampsia, gestational diabetes, obesity, spontaneous abortion, recurrent pregnancy, preterm labor, and intrauterine growth restriction. While a considerable number of miRNAs have been related to physiological functions and pathological conditions of the placenta, a direct link among these miRNAs, placental functions, and OS is still lacking. This review summarizes data describing the role of miRNAs in placental pathophysiological processes and their possible impact on OS damaging responses. As miRNAs can be found in circulation, improving our understanding on their role in the pathogenesis of pregnancy related disorders could have an important impact on the diagnosis and prognosis of these diseases.
已知氧化应激（OS）与大量胎儿、新生儿及成人疾病密切相关，包括胎盘疾病，可导致流产和死产。越来越多的研究将氧化应激与子痫前期、妊娠糖尿病、肥胖、自然流产、复发性妊娠、早产和宫内生长受限联系起来。虽然相当数量的微小RNA（miRNA）已被证明与胎盘的生理功能和病理状况有关，但这些miRNA、胎盘功能和氧化应激之间的直接联系仍然缺乏。本综述总结了描述miRNA在胎盘病理生理过程中的作用及其对氧化应激损伤反应可能影响的数据。由于miRNA可在循环中检测到，因此深入了解它们在妊娠相关疾病发病机制中的作用可能对这些疾病的诊断和预后产生重要影响。
