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Toll 样受体基因变异与结直肠癌。

Toll-like receptor genetic variants and colorectal cancer.

机构信息

Interfaculty Institute for Cell Biology; Department of Immunology; University of Tübingen; Tübingen, Germany.

Division of Molecular Genetic Epidemiology; German Cancer Research Center (DKFZ); Heidelberg, Germany ; Center for Primary Health Care Research; Clinical Research Center; Lund University; Malmö, Sweden.

出版信息

Oncoimmunology. 2014 Jan 1;3(1):e27763. doi: 10.4161/onci.27763. Epub 2014 Jan 10.

DOI:10.4161/onci.27763
PMID:24790794
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4004619/
Abstract

Single-nucleotide polymorphisms in Toll-like receptor 5 (), encoding a sensor for flagellin, have been shown to influence cytokine responses to intestinal bacteria and to be associated with significant alterations in the survival of colorectal carcinoma (CRC) patients. These findings point to a link between TLRs and CRC that may have both therapeutic and prognostic/predictive implications.

摘要

Toll 样受体 5 中的单核苷酸多态性（），编码鞭毛蛋白的传感器，已被证明会影响细胞因子对肠道细菌的反应，并与结直肠癌（CRC）患者的生存率显著改变相关。这些发现表明 TLR 与 CRC 之间存在联系，这可能具有治疗和预后/预测意义。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8631/4004619/344161101fc1/onci-3-e27763-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8631/4004619/344161101fc1/onci-3-e27763-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8631/4004619/344161101fc1/onci-3-e27763-g1.jpg

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本文引用的文献

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2
Identifying recent adaptations in large-scale genomic data.识别大规模基因组数据中的近期适应性变化。
Cell. 2013 Feb 14;152(4):703-13. doi: 10.1016/j.cell.2013.01.035.
3
Interleukin-6--a key regulator of colorectal cancer development.白细胞介素-6——结直肠癌发展的关键调节因子。
核苷酸结合寡聚化结构域样受体基因变异与结直肠癌发病风险及预后的相关性研究
PLoS One. 2018 Jun 21;13(6):e0199350. doi: 10.1371/journal.pone.0199350. eCollection 2018.
4
Investigation of single and synergic effects of NLRC5 and PD-L1 variants on the risk of colorectal cancer.NLRC5和PD-L1变体对结直肠癌风险的单一及协同效应研究。
PLoS One. 2018 Feb 6;13(2):e0192385. doi: 10.1371/journal.pone.0192385. eCollection 2018.
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Microbiota, Inflammation and Colorectal Cancer.微生物群、炎症与结直肠癌
Int J Mol Sci. 2017 Jun 20;18(6):1310. doi: 10.3390/ijms18061310.
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Pattern Recognition Receptors in Cancer Progression and Metastasis.癌症进展和转移中的模式识别受体
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