Interfaculty Institute for Cell Biology; Department of Immunology; University of Tübingen; Tübingen, Germany.
Division of Molecular Genetic Epidemiology; German Cancer Research Center (DKFZ); Heidelberg, Germany ; Center for Primary Health Care Research; Clinical Research Center; Lund University; Malmö, Sweden.
Oncoimmunology. 2014 Jan 1;3(1):e27763. doi: 10.4161/onci.27763. Epub 2014 Jan 10.
Single-nucleotide polymorphisms in Toll-like receptor 5 (), encoding a sensor for flagellin, have been shown to influence cytokine responses to intestinal bacteria and to be associated with significant alterations in the survival of colorectal carcinoma (CRC) patients. These findings point to a link between TLRs and CRC that may have both therapeutic and prognostic/predictive implications.
Toll 样受体 5 中的单核苷酸多态性（），编码鞭毛蛋白的传感器，已被证明会影响细胞因子对肠道细菌的反应，并与结直肠癌（CRC）患者的生存率显著改变相关。这些发现表明 TLR 与 CRC 之间存在联系，这可能具有治疗和预后/预测意义。
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