Division of Theoretical Chemistry and Biology, School of Biotechnology, KTH Royal Institute of Technology Stockholm, Sweden ; Department of Chemistry and Soft Matter Research Center, Zhejiang University Hangzhou, China.
Department of Chemistry and Soft Matter Research Center, Zhejiang University Hangzhou, China.
Front Chem. 2014 Feb 21;2:5. doi: 10.3389/fchem.2014.00005. eCollection 2014.
Owing to the potential use for real personalized genome sequencing, DNA sequencing with solid-state nanopores has been investigated intensively in recent time. However, the area still confronts problems and challenges. In this work, we present a brief overview of computational studies of key issues in DNA sequencing with solid-state nanopores by addressing the progress made in the last few years. We also highlight future challenges and prospects for DNA sequencing using this technology.
由于真正的个性化基因组测序具有潜在的应用前景，近年来，基于固态纳米孔的 DNA 测序技术得到了深入的研究。然而，该领域仍然面临着问题和挑战。在这项工作中，我们通过讨论过去几年取得的进展，对固态纳米孔 DNA 测序中的关键问题的计算研究进行了简要概述。我们还强调了使用这项技术进行 DNA 测序的未来挑战和前景。
