Fraunhofer Institute for Biomedical Engineering (IBMT), Am Muehlenberg 13, 14476 Potsdam-Golm, Germany.
Adv Colloid Interface Sci. 2014 May;207:306-24. doi: 10.1016/j.cis.2014.04.001. Epub 2014 Apr 12.
Porous CaCO₃ vaterite microparticles have been introduced a decade ago as sacrificial cores and becoming nowadays as one of the most popular templates to encapsulate bioactive molecules. This is due to the following beneficial features: i) mild decomposition conditions, ii) highly developed surface area, and iii) controlled size as well as easy and chip preparation. Such properties allow one to template and design particles with well tuned material properties in terms of composition, structure, functionality -- the parameters crucially important for bioapplications. This review presents a recent progress in utilizing the CaCO₃ cores for the assembly of micrometer-sized beads and capsules with encapsulated both small drugs and large biomacromolecules. Bioapplications of all the particles for drug delivery, biotechnology, and biosensing as well as future perspectives for templating are addressed.
多孔 CaCO₃ 文石型微米粒子作为牺牲核被引入已有十年，如今已成为封装生物活性分子的最受欢迎的模板之一。这是由于以下有益的特性：i）温和的分解条件，ii）高度发达的表面积，以及 iii）可控的尺寸以及易于制备和芯片制备。这些特性使得人们可以对粒子进行模板设计，从而对组成、结构、功能等材料性能进行微调，这些参数对于生物应用至关重要。这篇综述介绍了利用 CaCO₃ 核组装微米级珠粒和胶囊的最新进展，这些珠粒和胶囊封装了小分子药物和大分子生物聚合物。讨论了所有粒子在药物输送、生物技术和生物传感方面的生物应用以及模板的未来展望。
