Meeker John D, Cooper Ellen M, Stapleton Heather M, Hauser Russ
Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Nicholas School of the Environment, Duke University, Durham, NC, USA.
Endocr Disruptors (Austin). 2013 Oct 1;1(1):e26306. doi: 10.4161/endo.26306.
The use of phosphorus-containing flame retardants (PFRs) has increased over the past decade. Widespread human exposure has been reported, but information on the safety or potential health risks of PFRs is lacking. We assessed the relationship between urinary concentrations of two PFR metabolites [bis(1,3-dichloro-2-propyl) phosphate (BDCPP) and diphenyl phosphate (DPHP)] and semen quality, sperm motion parameters, and serum hormone levels in 33 men. BDCPP and DPHP concentrations were significantly greater in urine samples collected in the afternoon compared to those collected in the morning (p <0.05). In multivariable models, a number of statistically significant or suggestive associations were observed between the reproductive health measures and both PFR metabolites. While the study was limited by a small sample size, these results warrant further investigation in a larger study population. Additional studies on sources, pathways, and routes of PFR exposure, along with research on toxicokinetics and exposure measure utility, are also needed.
在过去十年中，含磷阻燃剂（PFRs）的使用有所增加。已有报告称人类广泛接触此类物质，但缺乏关于PFRs安全性或潜在健康风险的信息。我们评估了33名男性尿液中两种PFR代谢物[双（1,3 - 二氯 - 2 - 丙基）磷酸酯（BDCPP）和磷酸二苯酯（DPHP）]的浓度与精液质量、精子运动参数及血清激素水平之间的关系。与上午采集的尿液样本相比，下午采集的尿液样本中BDCPP和DPHP的浓度显著更高（p <0.05）。在多变量模型中，生殖健康指标与两种PFR代谢物之间均观察到了一些具有统计学意义或提示性的关联。尽管该研究受样本量较小的限制，但这些结果值得在更大的研究人群中进一步调查。还需要对PFR暴露的来源、途径和路线进行更多研究，同时开展关于毒代动力学和暴露测量效用的研究。
