Li Ying, Yu Haiming, Jiao Shunchang, Yang Junlan
Department of Medical Oncology, PLA General Hospital, Beijing 100853, China.
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2014 May;30(5):517-20.
To evaluate the prognostic value of IL-10 expression in breast cancer patients and determine the correlation between IL-10 expression and clinicopathological features of breast cancer.
Paraffin sections were retrospectively collected from 130 patients of stage I-III breast cancer who received surgery between January 2000 and December 2002 in the Chinese PLA General Hospital. The protein expression of IL-10 in the primary lesions was detected by immunohistochemistry to analyze the correlations of IL-10 expression with clinicopathological variables and prognosis.
IL-10 was found expressed in the cytoplasm of both tumor cells and stromal cells. Higher IL-10 expression in tumor cell cytoplasm was associated with lower T grade (P=0.012), higher SBR grade (P=0.004), positive ER (P=0.007), negative vascular invasion (P=0.034). The multivariant COX regression analysis showed that higher IL-10 expression in tumor cell cytoplasm was associated with better disease-free survival (HR=0.443, P=0.022) and that higher density of IL-10⁺; in stromal cell cytoplasm was associated with overall survival (HR=0.411, P=0.051).
IL-10 expression level in breast tumor cells and stromal cells can be used as a predictor of breast cancer prognosis. Low expression of IL-10 is associated with poor survival outcome.
评估白细胞介素-10（IL-10）表达在乳腺癌患者中的预后价值，并确定IL-10表达与乳腺癌临床病理特征之间的相关性。
回顾性收集2000年1月至2002年12月在中国人民解放军总医院接受手术的130例Ⅰ-Ⅲ期乳腺癌患者的石蜡切片。采用免疫组织化学法检测原发灶中IL-10的蛋白表达，分析IL-10表达与临床病理变量及预后的相关性。
发现肿瘤细胞和基质细胞的细胞质中均有IL-10表达。肿瘤细胞细胞质中IL-10表达较高与较低的T分级（P=0.012）、较高的SBR分级（P=0.004）、雌激素受体阳性（P=0.007）、无血管侵犯（P=0.034）相关。多变量COX回归分析显示，肿瘤细胞细胞质中IL-10表达较高与无病生存期较好相关（HR=0.443，P=0.022），基质细胞细胞质中IL-10⁺密度较高与总生存期相关（HR=0.411，P=0.051）。
乳腺肿瘤细胞和基质细胞中的IL-10表达水平可作为乳腺癌预后的预测指标。IL-10低表达与较差的生存结果相关。
