Gharsallah I, Souissi A, Dhahri R, Boussetta N, Sayeh S, Métoui L, Ajili F, Louzir B, Othmani S
Service de rhumatologie, hôpital militaire de Tunis, Tunis, Tunisie.
Service de dermatologie, hôpital militaire de Tunis, Tunis, Tunisie.
Rev Med Interne. 2014 Sep;35(9):595-600. doi: 10.1016/j.revmed.2013.12.018. Epub 2014 May 3.
SAPHO (synovitis, acne, pustulosis, hyperostosis, osteitis) syndrome is a rare entity characterized by the association of heterogeneous osteoarticular and cutaneous manifestations that have for common denominator an aseptic inflammatory process. The etiopathogeny of this disease is still a matter of debate. Although it has been related to the spondylarthritis family, an infectious origin is suggested. Diagnosis is based on the presence of at least one of the three diagnostic criteria proposed by Kahn. The treatment includes NSAIDs, antibiotics, corticosteroids, methotrexate and more recently the bisphosphonates and the TNFα inhibitors.
SAPHO（滑膜炎、痤疮、脓疱病、骨质增生、骨炎）综合征是一种罕见病症，其特征为多种不同的骨关节和皮肤表现同时出现，这些表现的共同特点是存在无菌性炎症过程。该疾病的病因仍存在争议。尽管它被认为与脊柱关节炎家族有关，但也有人提出其起源可能是感染性的。诊断基于卡恩提出的三项诊断标准中至少一项的存在。治疗方法包括非甾体抗炎药、抗生素、皮质类固醇、甲氨蝶呤，以及最近使用的双膦酸盐和肿瘤坏死因子α抑制剂。
