World Premier International Center for Materials Nanoarchitectonics (WPI-MANA), National Institute for Materials Science (NIMS) , Namiki 1-1, Tsukuba, Ibaraki 305-0044, Japan.
ACS Nano. 2014 Jun 24;8(6):6123-30. doi: 10.1021/nn5014808. Epub 2014 May 7.
Developing materials for "Nano-vehicles" with clinically approved drugs encapsulated is envisaged to enhance drug therapeutic effects and reduce the adverse effects. However, design and preparation of the biomaterials that are porous, nontoxic, soluble, and stable in physiological solutions and could be easily functionalized for effective drug deliveries are still challenging. Here, we report an original and simple thermal substitution method to fabricate perfectly water-soluble and porous boron nitride (BN) materials featuring unprecedentedly high hydroxylation degrees. These hydroxylated BNs are biocompatible and can effectively load anticancer drugs (e.g., doxorubicin, DOX) up to contents three times exceeding their own weight. The same or even fewer drugs that are loaded on such BN carriers exhibit much higher potency for reducing the viability of LNCaP cancer cells than free drugs.
我们设想用临床批准的药物包裹来开发“纳米载体”材料，以提高药物的疗效并降低不良反应。然而，设计和制备多孔、无毒、可溶于生理溶液且稳定的生物材料，并能方便地进行有效药物输送的功能化，仍然具有挑战性。在这里，我们报告了一种原创且简单的热取代方法来制备具有前所未有的高羟基化度的完全水溶性和多孔氮化硼 (BN) 材料。这些羟基化 BN 是生物相容的，能够有效负载抗癌药物（如阿霉素，DOX），其含量高达自身重量的三倍以上。负载在 BN 载体上的相同甚至更少的药物，其降低 LNCaP 癌细胞活力的效果比游离药物高得多。
