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氟西汀单独及与氟康唑联合使用时的抗念珠菌活性：对氟康唑耐药菌株的协同作用。

Anti-Candida activity of fluoxetine alone and combined with fluconazole: a synergistic action against fluconazole-resistant strains.

作者信息

Oliveira Ana S, Gaspar Carlos A, Palmeira-de-Oliveira Rita, Martinez-de-Oliveira José, Palmeira-de-Oliveira Ana

机构信息

CICS-UBI, Health Sciences Research Center, Faculty of Health Sciences, University of Beira Interior, Covilhã, Portugal.

CICS-UBI, Health Sciences Research Center, Faculty of Health Sciences, University of Beira Interior, Covilhã, Portugal Hospital Pharmacy Department, Centro Hospitalar Cova da Beira EPE, Covilhã, Portugal.

出版信息

Antimicrob Agents Chemother. 2014 Jul;58(7):4224-6. doi: 10.1128/AAC.02623-13. Epub 2014 May 5.

DOI:10.1128/AAC.02623-13
PMID:24798281
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4068595/
Abstract

The purpose of this work was to determine the antimicrobial activity of fluoxetine, alone and combined with fluconazole, against 29 Candida strains isolated from patients with vulvovaginal candidiasis. MIC and minimum lethal concentration values ranged from 9.8 to 625 μg/ml for all strains tested. The combination of fluconazole with fluoxetine resulted in synergistic activity against six Candida strains, with fractional inhibitory index (FIX) values between 0.15 and 0.31. An indifferent effect was found for the remaining strains, with FIX values between 0.63 and 1.

摘要

这项工作的目的是确定氟西汀单独及与氟康唑联合使用时，对从外阴阴道念珠菌病患者中分离出的29株念珠菌的抗菌活性。所有测试菌株的最低抑菌浓度（MIC）和最低致死浓度值范围为9.8至625μg/ml。氟康唑与氟西汀联合使用对6株念珠菌产生协同活性，部分抑菌指数（FIX）值在0.15至0.31之间。其余菌株呈现无关作用，FIX值在0.63至1之间。

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