Zhao Zhiming, Li Chenggang, Hu Minggeng, Li Jidong, Liu Rong
Department of Surgical Oncology, Chinese PLA General Hospital, 100853, Beijing, China,
Tumour Biol. 2014 Aug;35(8):7629-33. doi: 10.1007/s13277-014-1978-x. Epub 2014 May 6.
The etiology of pancreatic cancer (PC) remains poorly understood. High iron levels can increase the formation of noxious oxygen radicals, which are thought to promote carcinogenesis. The aim of this study was to determine whether iron biomarkers and HFE genotypes, which influence iron regulation, constitute risk factors for PC. A case-control study was conducted to examine plasma ferritin levels (n = 1,000 cases; 1,004 controls), two hemochromatosis gene (HFE) SNPs (n = 1,386 cases; 1,386 controls), and PC risk. Odds ratios (ORs) and 95 % confidence intervals (CIs) were calculated by unconditional logistic regression. We did not observe a significant association between plasma ferritin and PC risk. However, HFE rs1799945 was significantly associated with PC risk, with each additional copy of minor allele T being associated with a 1.21-fold increased risk of PC (OR = 1.21, 95 % CI 1.05-1.39, P = 7.72 × 10(-3)). Overall, high iron levels do not increase the risk of PC. Our observation that HFE rs1799945 increased PC risk warrants replication in additional study populations.
胰腺癌（PC）的病因仍未完全明确。高铁水平会增加有害氧自由基的形成，而氧自由基被认为会促进癌症发生。本研究的目的是确定影响铁调节的铁生物标志物和HFE基因分型是否构成PC的风险因素。开展了一项病例对照研究，以检测血浆铁蛋白水平（1000例病例；1004例对照）、两个血色素沉着症基因（HFE）单核苷酸多态性（1386例病例；1386例对照）以及PC风险。通过非条件逻辑回归计算比值比（OR）和95%置信区间（CI）。我们未观察到血浆铁蛋白与PC风险之间存在显著关联。然而，HFE rs1799945与PC风险显著相关，次要等位基因T每增加一个拷贝，PC风险增加1.21倍（OR = 1.21，95% CI 1.05 - 1.39，P = 7.72×10⁻³）。总体而言，高铁水平不会增加PC风险。我们观察到HFE rs1799945增加PC风险这一结果有待在其他研究人群中进行重复验证。
