Nizam Nejat, Gümüş Pınar, Pitkänen Jari, Tervahartiala Taina, Sorsa Timo, Buduneli Nurcan
Department of Periodontology, School of Dentistry, Ege University, 35100, Bornova, İzmir, Turkey.
Inflammation. 2014 Oct;37(5):1771-8. doi: 10.1007/s10753-014-9907-0.
Salivary, serum matrix metalloproteinase-8 (MMP-8), tissue inhibitor of matrix metalloproteinases-1 (TIMP-1), neutrophil elastase (NE), and myeloperoxidase (MPO) levels were investigated in generalized chronic periodontitis (GCP), generalized aggressive periodontitis (GAgP), and healthy groups. Whole-mouth clinical periodontal measurements were recorded. Salivary, serum concentrations of MMP-8, MPO, TIMP-1, and NE were determined by immunofluorometric assay or ELISA in 18 patients with GCP, 23 patients with GAgP, 18 individuals with healthy periodontium. Patients in the GAgP group were younger than the other groups (p<0.05). The study groups were similar in gender, smoking status. Plaque index was higher in GCP than GAgP group (p<0.05). Biochemical data were similar in periodontitis groups. Salivary, serum MPO, and salivary NE concentrations were higher; TIMP-1 concentrations were lower in the periodontitis groups than the controls (p<0.05). The present data support a close relationship between salivary, serum protease content and clinical periodontal parameters in patients with generalized periodontitis.
研究了慢性广泛型牙周炎（GCP）、广泛型侵袭性牙周炎（GAgP）和健康组唾液、血清中基质金属蛋白酶-8（MMP-8）、基质金属蛋白酶组织抑制剂-1（TIMP-1）、中性粒细胞弹性蛋白酶（NE）和髓过氧化物酶（MPO）的水平。记录全口临床牙周测量数据。采用免疫荧光分析法或酶联免疫吸附测定法测定了18例GCP患者、23例GAgP患者和18例牙周健康个体唾液、血清中MMP-8、MPO、TIMP-1和NE的浓度。GAgP组患者比其他组患者年轻（p<0.05）。研究组在性别、吸烟状况方面相似。GCP组的菌斑指数高于GAgP组（p<0.05）。牙周炎组的生化数据相似。牙周炎组唾液、血清MPO以及唾液NE浓度较高；TIMP-1浓度低于对照组（p<0.05）。目前的数据支持了广泛型牙周炎患者唾液、血清蛋白酶含量与临床牙周参数之间存在密切关系。
