Peselow Eric, Pi Sarah, Lopez Enrique, Besada André, Ishak Waguih William
Dr. Peselow is from the Richmond University Medical Center and Freedom From Fear, Staten Island, New York; Ms. Pi, Dr. Lopez, Mr. Besada, and Dr. IsHak are from Cedars-Sinai Medical Center, Los Angeles, California.
Innov Clin Neurosci. 2014 Mar;11(3-4):17-23.
The authors sought to assess spirituality in depressed patients and evaluate whether the degree of initial depressive symptoms and response to pharmacotherapy treatment has a correlation with degree of spirituality and belief in God.
Our participants included 84 patients who presented to a depression/anxiety clinic for naturalistic treatment of their depressive illness over the course of two years. All patients met the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision criteria for major depression, as confirmed by structured interviews using the Structured Clinical Interview for DSM-IV, and were treated with selective serotonin reuptake inhibitors for eight weeks.
Patients were evaluated at baseline and after treatment using the Montgomery Asberg Depression Rating Scale, the Beck Hopelessness Scale, the Dysfunctional Attitude Scale, and the Spiritual Orientation to Life scale.
At baseline, patients reporting greater spirituality had significantly lower measures of hopelessness, dysfunctional attitudes, and depressive symptoms. Those who believed in God had a greater mean change score than those who did not on the Montgomery Asberg Depression Rating Scale, the Beck Hopelessness Scale, and the Dysfunctional Attitude Scale, with the Montgomery Asberg Depression Rating Scale showing the greatest mean change score. Significant correlations were detected between the Spiritual Orientation to Life scale score and the Montgomery Asberg Depression Rating Scale, the Beck Hopelessness Scale, and the Dysfunctional Attitude Scale pre-scores, post-scores, and change scores.
The findings suggest that greater spirituality is associated with less severe depression. Moreover, the degree to which the measures of depressive symptom severity, hopelessness, and cognitive distortions improved over the course of eight weeks was significantly greater for those patients who were more spiritual.
作者试图评估抑郁症患者的精神性，并评估初始抑郁症状的程度以及药物治疗反应是否与精神性程度和对上帝的信仰相关。
我们的参与者包括84名在两年期间前往抑郁/焦虑诊所接受抑郁症自然疗法的患者。所有患者均符合《精神障碍诊断与统计手册》第四版，修订版中重度抑郁症的标准，这通过使用DSM-IV的结构化临床访谈进行的结构化访谈得到证实，并接受了8周的选择性5-羟色胺再摄取抑制剂治疗。
使用蒙哥马利-阿斯伯格抑郁评定量表、贝克绝望量表、功能失调态度量表和生活精神取向量表在基线和治疗后对患者进行评估。
在基线时，报告精神性更强的患者在绝望、功能失调态度和抑郁症状方面的测量值显著更低。在蒙哥马利-阿斯伯格抑郁评定量表、贝克绝望量表和功能失调态度量表上，相信上帝的患者的平均变化得分高于不相信上帝的患者，其中蒙哥马利-阿斯伯格抑郁评定量表显示出最大的平均变化得分。在生活精神取向量表得分与蒙哥马利-阿斯伯格抑郁评定量表、贝克绝望量表和功能失调态度量表的预得分、后得分及变化得分之间检测到显著相关性。
研究结果表明，更强的精神性与不太严重的抑郁症相关。此外，对于那些精神性更强的患者，抑郁症状严重程度、绝望和认知扭曲的测量值在八周的过程中改善的程度显著更大。
