Bindea Gabriela, Mlecnik Bernhard, Angell Helen K, Galon Jérôme
INSERM U872; Laboratory of Integrative Cancer Immunology; Paris, France ; Université Paris Descartes; Paris, France ; Cordeliers Research Centre; Université Pierre et Marie Curie Paris 6; Paris, France.
INSERM U872; Laboratory of Integrative Cancer Immunology; Paris, France ; Université Paris Descartes; Paris, France ; Cordeliers Research Centre; Université Pierre et Marie Curie Paris 6; Paris, France ; Molecular Pathology Group; AstraZeneca; Alderley Park; Cheshire, UK.
Oncoimmunology. 2014 Jan 1;3(1):e27456. doi: 10.4161/onci.27456. Epub 2014 Jan 3.
Understanding the spontaneous immune response of cancer patients is critical for the design of efficient anticancer immunotherapies. The power of integrative tumor immunology approaches allowed for a comprehensive view of the immune system evolution in the course of tumor progression and recurrence. We have demonstrated that tumor-infiltrating immune cells are spatiotemporally regulated, a finding that has profound implications for the development of efficient anticancer immunotherapies.
了解癌症患者的自发免疫反应对于设计有效的抗癌免疫疗法至关重要。综合肿瘤免疫学方法的强大功能使人们能够全面了解肿瘤进展和复发过程中免疫系统的演变。我们已经证明肿瘤浸润免疫细胞受到时空调节，这一发现对开发有效的抗癌免疫疗法具有深远意义。
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