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CluePedia Cytoscape 插件：使用整合的实验和计算数据进行通路分析。

CluePedia Cytoscape plugin: pathway insights using integrated experimental and in silico data.

机构信息

INSERM, Laboratory of Integrative Cancer Immunology, 75006 Paris, France.

出版信息

Bioinformatics. 2013 Mar 1;29(5):661-3. doi: 10.1093/bioinformatics/btt019. Epub 2013 Jan 16.

DOI:10.1093/bioinformatics/btt019
PMID:23325622
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3582273/
Abstract

SUMMARY

The CluePedia Cytoscape plugin is a search tool for new markers potentially associated to pathways. CluePedia calculates linear and non-linear statistical dependencies from experimental data. Genes, proteins and miRNAs can be connected based on in silico and/or experimental information and integrated into a ClueGO network of terms/pathways. Interrelations within each pathway can be investigated, and new potential associations may be revealed through gene/protein/miRNA enrichments. A pathway-like visualization can be created using the Cerebral plugin layout. Combining all these features is essential for data interpretation and the generation of new hypotheses. The CluePedia Cytoscape plugin is user-friendly and has an expressive and intuitive visualization.

AVAILABILITY

http://www.ici.upmc.fr/cluepedia/ and via the Cytoscape plugin manager. The user manual is available at the CluePedia website.

摘要

摘要

CluePedia Cytoscape 插件是一个用于搜索新的与通路相关的潜在标志物的工具。CluePedia 可以根据实验数据计算线性和非线性的统计相关性。基因、蛋白质和 miRNA 可以根据计算机模拟和/或实验信息进行连接，并整合到 ClueGO 术语/通路网络中。可以在每个通路内调查它们之间的相互关系，并通过基因/蛋白质/miRNA 的富集来揭示新的潜在关联。可以使用 Cerebral 插件布局创建类似通路的可视化效果。结合所有这些功能对于数据解释和生成新的假设至关重要。CluePedia Cytoscape 插件易于使用，具有表现力和直观的可视化效果。

可用性

http://www.ici.upmc.fr/cluepedia/ 和通过 Cytoscape 插件管理器。用户手册可在 CluePedia 网站上获得。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbfe/3582273/4d0a2d4079a3/btt019f1p.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbfe/3582273/4d0a2d4079a3/btt019f1p.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbfe/3582273/4d0a2d4079a3/btt019f1p.jpg

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