向大鼠下丘脑内注射大麻二酚可提高伏隔核中腺苷的细胞外水平。
Intrahypothalamic injection of cannabidiol increases the extracellular levels of adenosine in nucleus accumbens in rats.
作者信息
Mijangos-Moreno Stephanie, Poot-Aké Alwin, Arankowsky-Sandoval Gloria, Murillo-Rodríguez Eric
机构信息
Laboratorio de Neurociencias Moleculares e Integrativas, Escuela de Medicina, División Ciencias de la Salud, Universidad Anáhuac Mayab, Mérida, Yucatán, Mexico.
Laboratorio de Neurobiología, Departamento de Neurociencias, Centro de Investigaciones Regionales "Dr. Hideyo Noguchi", Universidad Autónoma de Yucatán, Mérida, Yucatán, Mexico.
出版信息
Neurosci Res. 2014 Jul;84:60-3. doi: 10.1016/j.neures.2014.04.006. Epub 2014 May 4.
Cannabidiol (CBD) is a constituent of Cannabis sativa that promotes wakefulness as well as enhances endogenous levels of wake-related neurotransmitters, including dopamine. However, at this date, the effects of CBD on the sleep-inducing molecules, such as adenosine (AD), are unknown. Here, we report that intrahypothalamic injection of CBD (10μg/1μL) increases the extracellular levels of AD collected from nucleus accumbens. Furthermore, the pharmacodynamic of this drug shows that effects on the contents of AD last 2h post-injection. These preliminary findings suggest that CBD promotes the endogenous accumulation of AD.
大麻二酚（CBD）是大麻的一种成分，可促进清醒并提高包括多巴胺在内的与清醒相关的神经递质的内源性水平。然而，截至目前，CBD对诸如腺苷（AD）等诱导睡眠分子的影响尚不清楚。在此，我们报告下丘脑内注射CBD（10μg/1μL）可增加从伏隔核收集的细胞外AD水平。此外，该药物的药效学表明，对AD含量的影响在注射后持续2小时。这些初步发现表明，CBD可促进AD的内源性积累。
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