Bellido Elena, Guillevic Mazheva, Hidalgo Tania, Santander-Ortega Manuel J, Serre Christian, Horcajada Patricia
Institut Lavoisier de Versailles, UMR CNRS 8180, Université de Versailles Saint-Quentin-en-Yvelines , 45 avenue des Etats-Unis, 78035 Versailles cedex, France.
Langmuir. 2014 May 27;30(20):5911-20. doi: 10.1021/la5012555. Epub 2014 May 14.
The colloidal and chemical stability of nanoparticles of the nontoxic and biodegradable iron(III) trimesate MIL-100(Fe) nanocarrier have been evaluated in the presence of a series of simulated physiological fluids for intravenous and oral administration. MIL-100(Fe) nanoparticles exhibit an appropriate colloidal stability and biodegradability, mainly dependent on both the nature of their physicochemical surface and the media composition, being a priori compatible with their biomedical use.
已在一系列用于静脉注射和口服给药的模拟生理流体存在的情况下，评估了无毒且可生物降解的均苯三甲酸铁（III）MIL-100（Fe）纳米载体纳米颗粒的胶体稳定性和化学稳定性。MIL-100（Fe）纳米颗粒表现出适当的胶体稳定性和生物降解性，这主要取决于其物理化学表面的性质和介质组成，从先验角度看与它们的生物医学用途兼容。
