Rodríguez Santana Yesica, Nimo Román Andrea, García Sáez Iker, López Alvarez José Manuel, Consuegra Llapur Eduardo, González Jorge Rafael
Pediatric Intensive Care Unit, Hospital Universitario Materno-Infantil, 35016 Las Palmas de Gran Canaria, Spain.
Case Rep Crit Care. 2011;2011:293917. doi: 10.1155/2011/293917. Epub 2011 Jun 27.
Severe hypertriglyceridemia (SH) represents a therapeutic emergency because of the possibility of developing cardiovascular events and hyperlipemic acute pancreatitis (PA). Most patients with SH suffer primary or genetic abnormality in lipid metabolism in combination with a precipitating factor such as uncontrolled diabetes mellitus, alcoholism, and drug intake. The standard treatment of hypertriglyceridemia (HTG) with omega 3 fatty acids and fibrates, along with dietary changes, has no effect on an emergency situation. There are no clinical guidelines to SH, but therapy with insulin, heparin, a combination of both, plasmapheresis, or octreotide have been tested succesfully. We report the case of a 10-year-old girl with clinical acute pancreatitis and diabetic ketoacidosis debut, along with incidental finding of an SH, who had a good outcome after treatment with insulin intravenous infusion.
严重高甘油三酯血症（SH）是一种治疗急症，因为有可能发生心血管事件和高脂血症性急性胰腺炎（PA）。大多数SH患者存在脂质代谢的原发性或遗传性异常，并伴有诸如未控制的糖尿病、酗酒和药物摄入等促发因素。使用ω-3脂肪酸和贝特类药物对高甘油三酯血症（HTG）进行标准治疗，同时改变饮食，对紧急情况无效。目前尚无针对SH的临床指南，但胰岛素、肝素、两者联合、血浆置换或奥曲肽治疗已被成功测试。我们报告一例10岁女孩，以临床急性胰腺炎和糖尿病酮症酸中毒起病，同时偶然发现患有SH，经静脉输注胰岛素治疗后预后良好。
