Tolento Cortes Luis, Trinh Jessica, Le Mimi, Papayanis Philip, Tudtud-Hans Leah, Hong Lisa
Loma Linda University Health, School of Pharmacy, 24745 Stewart St, Loma Linda, CA, USA.
Loma Linda University Health, School of Medicine, 11175 Campus St, Loma Linda, CA, USA.
Case Rep Endocrinol. 2022 Sep 27;2022:7905552. doi: 10.1155/2022/7905552. eCollection 2022.
Acute pancreatitis (AP) leads to a variety of complications, such as local or systemic inflammatory responses as well as organ failure. While choledocholithiasis and alcohol abuse are two of the most common causes of AP, hypertriglyceridemia causes AP with an incidence rate between 2 and 5%. The management of hypertriglyceridemia-induced pancreatitis (HTGIP) is focused on the lowering of triglyceride (TG) levels, and the efficacy of therapies for the management of HTGIP may vary based on the hypertriglyceridemia etiology. The aim of this article is to report a case of a 43-year-old female with a history of familial hypertriglyceridemia and without diabetes who was admitted for acute pancreatitis with a TG level elevated to 4,435 mg/dL. The patient was treated with a combination of insulin, heparin, atorvastatin, and omega-3-acid ethyl esters, and her TG level was reduced to 880 mg/dL after 9 days of therapy. Despite the successful treatment of the patient, standardization of the approach for the treatment of HTGIP is needed. Future research should aim to identify the appropriateness of insulin therapy specifically in patients without diabetes presenting with hypertriglyceridemia and the dosing associated with optimal safety.
急性胰腺炎（AP）会引发多种并发症，如局部或全身炎症反应以及器官衰竭。虽然胆总管结石和酗酒是AP最常见的两种病因，但高甘油三酯血症导致的AP发病率在2%至5%之间。高甘油三酯血症性胰腺炎（HTGIP）的治疗重点是降低甘油三酯（TG）水平，且治疗HTGIP的疗法疗效可能因高甘油三酯血症的病因不同而有所差异。本文旨在报告一例43岁女性患者，该患者有家族性高甘油三酯血症病史且无糖尿病，因急性胰腺炎入院，其TG水平升至4435mg/dL。该患者接受了胰岛素、肝素、阿托伐他汀和ω-3酸乙酯联合治疗，治疗9天后其TG水平降至880mg/dL。尽管患者治疗成功，但仍需要对HTGIP的治疗方法进行标准化。未来的研究应致力于确定胰岛素治疗在无糖尿病的高甘油三酯血症患者中的适用性以及与最佳安全性相关的剂量。
