Ethn Dis. 2014 Spring;24(2):207-12.
Our study aimed to study the impact of obesity and metabolic syndrome (MetS) on lipoprotein profiles and cardiovascular risk through lipid ratios and atherogenic index of plasma (AIP) in Moroccan women.
Our study included 240 Moroccan women, aged 53.31 +/- 8.51 years, divided into three groups: controls (group 1, n = 80), obese without MetS (group 2, n = 80) and obese with MetS (group 3, n = 80). Anthropometric and lipid measurements were taken and specific lipid ratios assessed, as well as Non-HDL cholesterol (Non-HDL-C) and atherogenic index of plasma (ALP).
Group 2 presented similar lipoprotein profiles compared with group 1. Group 3 had higher triglyceride (TG) levels than group 1, which, in turn, increased HDL and AIP values. Dyslipidemia in group 3 was demonstrated by higher TG levels, lipid ratios and AIP and lower HDL-C levels compared with group 2. All of these abnormalities are responsible for elevations of risks of cardiovascular diseases. Closer associations were found between cardiovascular risk and lipid ratios and AIP than lipids alone.
Our study confirms that MetS affects the serum lipoprotein profile of obese women. Lipid ratios, non HDL-C and AIP remain useful tools for the diagnosis and prognosis of cardiovascular disease by their associations with lipid parameters and their high predictive values.
本研究旨在通过血脂比值和血浆致动脉粥样硬化指数（AIP）研究肥胖和代谢综合征（MetS）对摩洛哥女性脂蛋白谱和心血管风险的影响。
本研究纳入了 240 名年龄为 53.31±8.51 岁的摩洛哥女性，分为三组：对照组（第 1 组，n=80）、非 MetS 肥胖组（第 2 组，n=80）和 MetS 肥胖组（第 3 组，n=80）。测量了人体测量学和血脂指标，并评估了特定的血脂比值以及非高密度脂蛋白胆固醇（Non-HDL-C）和血浆致动脉粥样硬化指数（AIP）。
与第 1 组相比，第 2 组的脂蛋白谱相似。第 3 组的甘油三酯（TG）水平高于第 1 组，而第 1 组的 HDL 和 AIP 值则升高。与第 2 组相比，第 3 组的血脂异常表现为 TG 水平升高、血脂比值和 AIP 升高以及 HDL-C 水平降低。所有这些异常都导致了心血管疾病风险的增加。与血脂相比，心血管风险与血脂比值和 AIP 的相关性更强。
本研究证实 MetS 会影响肥胖女性的血清脂蛋白谱。血脂比值、非 HDL-C 和 AIP 通过与血脂参数的关联及其高预测值，仍然是心血管疾病诊断和预后的有用工具。
