载脂蛋白C-III的淀粉样三角形、正方形和环。
Amyloid triangles, squares, and loops of apolipoprotein C-III.
作者信息
de Messieres Michel, Huang Rick K, He Yi, Lee Jennifer C
机构信息
Laboratory of Molecular Biophysics and ‡Protein Expression Facility, Biochemistry and Biophysics Center, National Heart, Lung, and Blood Institute, and §Laboratory of Structural Biology Research, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health , Bethesda, Maryland 20892, United States.
出版信息
Biochemistry. 2014 May 27;53(20):3261-3. doi: 10.1021/bi500502d. Epub 2014 May 13.
Abstract
While a significant component of atherosclerotic plaques has been characterized as amyloid, the specific proteins remain to be fully identified. Probable amyloidogenic proteins are apolipoproteins (Apos), which are vital for the formation and function of lipoproteins. ApoCIII is an abundant protein implicated in atherosclerosis, and we show it forms a ribbonlike looped amyloid, strikingly similar to that previously reported for ApoAI and ApoCII. Triangles and squares with a width of ~50 nm were also observed, which may be a novel form of amyloid or related to previously reported amyloid rings.
摘要
虽然动脉粥样硬化斑块的一个重要组成部分已被鉴定为淀粉样蛋白，但具体的蛋白质仍有待完全确定。可能形成淀粉样蛋白的蛋白质是载脂蛋白（Apos），它们对脂蛋白的形成和功能至关重要。载脂蛋白CIII是一种与动脉粥样硬化有关的丰富蛋白质，我们发现它形成了一种带状环状淀粉样蛋白，与先前报道的载脂蛋白AI和载脂蛋白CII惊人地相似。还观察到宽度约为50纳米的三角形和正方形，这可能是一种新型的淀粉样蛋白形式或与先前报道的淀粉样蛋白环有关。
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