Laboratory of Protein Conformation and Dynamics, Biochemistry and Biophysics Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Chem Commun (Camb). 2018 Jun 21;54(51):6983-6986. doi: 10.1039/c8cc03217c.
Structural differences in pathological and functional amyloid fibrils have been investigated by Raman microspectroscopy. Second-derivative analyses of amide-I and amide-III bands distinguish parallel in-register β-sheets from a β-solenoid. Further, spatially resolved Raman spectra reveal molecular heterogeneity in amyloid structures.
拉曼微光谱研究了病理性和功能性淀粉样纤维的结构差异。酰胺 I 和酰胺 III 带的二阶导数分析将平行的、对位的β-片层与β-螺旋区分开来。此外，空间分辨拉曼光谱揭示了淀粉样结构中的分子异质性。
