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常规低脂奶制品单独添加到日常饮食中对血压的影响:一项随机对照试验。

Hypotensive effects of solitary addition of conventional nonfat dairy products to the routine diet: a randomized controlled trial.

机构信息

From the Cardiovascular Aging Research Laboratory, Department of Kinesiology and Health Education, The University of Texas at Austin, Austin, TX.

出版信息

Am J Clin Nutr. 2014 Jul;100(1):80-7. doi: 10.3945/ajcn.114.085761. Epub 2014 May 7.

Abstract

BACKGROUND

The high consumption of low-fat and nonfat dairy products is associated with reduced risk of high blood pressure.

OBJECTIVE

We aimed to investigate whether the solitary addition of nonfat dairy products to the normal routine diet was capable of lowering blood pressure in middle-aged and older adults with elevated blood pressure.

DESIGN

With the use of a randomized, crossover intervention-study design, 49 adults (56% women) with elevated blood pressure (mean ± SEM age: 53 ± 2 y; systolic blood pressure: 135 ± 1; diastolic blood pressure: 80 ± 1 mm Hg) underwent a high-dairy condition (+4 servings conventional nonfat dairy products/d) and isocaloric no-dairy condition (+4 servings fruit products/d) in which all dairy products were removed. Both dietary conditions lasted 4 wk with a 2-wk washout before crossing over into the alternate condition.

RESULTS

The high-dairy condition produced reductions in systolic blood pressure (135 ± 1 to 127 ± 1 mm Hg) and pulse pressure (54 ± 1 to 48 ± 1 mm Hg) (both P < 0.05). The hypotensive effects were observed within 3 wk after the initiation of the dietary intervention and in both casual seated and ambulatory (24-h) measurements (P < 0.05). Pulse pressure was increased after the removal of all dairy products in the no-dairy condition (54 ± 1 to 56 ± 1 mm Hg; P < 0.05). There were no changes in diastolic blood pressure after either dietary condition.

CONCLUSION

We concluded that the solitary manipulation of conventional dairy products in the normal routine diet would modulate blood pressure in middle-aged and older adults with prehypertension and hypertension. This trial was registered at clinicaltrials.gov as NCT01577030.

摘要

背景

大量食用低脂和脱脂乳制品与降低高血压风险有关。

目的

我们旨在研究在血压升高的中年和老年人中,正常日常饮食中单独添加脱脂乳制品是否能够降低血压。

设计

采用随机、交叉干预研究设计,49 名血压升高的成年人(56%为女性)(平均 ± SEM 年龄:53 ± 2 岁;收缩压:135 ± 1;舒张压:80 ± 1mmHg)接受高乳制品饮食(+4 份常规脱脂乳制品/天)和等热量无乳制品饮食(+4 份水果产品/天),其中所有乳制品均被去除。两种饮食条件持续 4 周,然后进行 2 周洗脱期,再进入交替条件。

结果

高乳制品饮食可降低收缩压(135 ± 1 至 127 ± 1mmHg)和脉压(54 ± 1 至 48 ± 1mmHg)(均 P < 0.05)。这些降压作用在饮食干预开始后 3 周内观察到,并在偶然的坐姿和动态(24 小时)测量中均有观察到(均 P < 0.05)。在无乳制品饮食中,所有乳制品被去除后,脉压增加(54 ± 1 至 56 ± 1mmHg;P < 0.05)。两种饮食条件后舒张压均无变化。

结论

我们得出结论,正常日常饮食中常规乳制品的单独调整可调节血压升高的中年和老年人的血压。本试验在 clinicaltrials.gov 上注册为 NCT01577030。

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