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电针 PC6 或 ST36 影响他克林对食管动力的影响。

Electroacupuncture at PC6 or ST36 Influences the Effect of Tacrine on the Motility of Esophagus.

机构信息

Department of Gastroenterology, Peking University First Hospital, 8 Xishiku Street, Beijing 100034, China.

出版信息

Evid Based Complement Alternat Med. 2014;2014:263489. doi: 10.1155/2014/263489. Epub 2014 Apr 7.

DOI:10.1155/2014/263489
PMID:24808917
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3997975/
Abstract

Aim. To investigate the mechanisms of gastrointestinal side effects of tacrine, and find treatment methods with electroacupuncture (EA). Methods. Twenty-five healthy cats were randomly divided into 5 groups: gastric-distention group (model group), tacrine group (cholinesterase inhibitor), tacrine + sham acupoint group (control group), tacrine + PC6 (neiguan) group, and tacrine + ST36 (zusanli) group, with 5 cats in each group. Saline 2 mL i.p. was given 30 min before gastric distention in model group. Tacrine 5.6 mg/kg i.p. was given 30 minutes before gastric distention in the other groups. Tacrine + sham acupoint group (control group), tacrine + PC6 group, and tacrine + ST36 group received EA at corresponding acupoints during gastric distention. The frequency of TLESRs and LESP were recorded by using a perfused sleeve assembly. Results. Compared with the model group, tacrine significantly increased the frequency of gastric distention-induced TLESR (P < 0.05) but did not influence the rate of common cavity during TLESR. Tacrine significantly increased the LESP, which could not remain during gastric distention. EA at PC6 could decrease the frequency of TLESR and maintain the increase of LESP, but EA at ST36 did not have these effects. Conclusion. Tacrine can significantly increase the gastric distention-induced transient lower esophageal sphincter relaxations (TLESRs). Electroacupuncture (EA) at PC6 may reverse the above side effect.

摘要

目的。研究他克林胃肠道副作用的机制，并寻找电针（EA）的治疗方法。方法。25 只健康猫随机分为 5 组：胃扩张组（模型组）、他克林组（胆碱酯酶抑制剂）、他克林+假穴位组（对照组）、他克林+PC6（内关）组和他克林+ST36（足三里）组，每组 5 只猫。模型组在胃扩张前 30 分钟给予 2ml 生理盐水。其他组在胃扩张前 30 分钟给予他克林 5.6mg/kg 腹腔注射。他克林+假穴位组（对照组）、他克林+PC6 组和他克林+ST36 组在胃扩张期间接受相应穴位的电针治疗。使用灌注套管组件记录 TLESR 和 LESP 的频率。结果。与模型组相比，他克林显著增加了胃扩张诱导的 TLESR 频率（P<0.05），但不影响 TLESR 期间共同腔的比率。他克林显著增加了 LESP，在胃扩张期间不能保持。PC6 处的 EA 可降低 TLESR 的频率并维持 LESP 的增加，但 ST36 处的 EA 没有这些作用。结论。他克林可显著增加胃扩张诱导的短暂性食管下括约肌松弛（TLESRs）。电针（EA）在 PC6 可能逆转上述副作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0c9/3997975/634fb4cc75a0/ECAM2014-263489.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0c9/3997975/65334766ad18/ECAM2014-263489.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0c9/3997975/23cdcd63785d/ECAM2014-263489.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0c9/3997975/634fb4cc75a0/ECAM2014-263489.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0c9/3997975/65334766ad18/ECAM2014-263489.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0c9/3997975/23cdcd63785d/ECAM2014-263489.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0c9/3997975/634fb4cc75a0/ECAM2014-263489.003.jpg

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[Electroacupuncture at "Zusanli"(ST 36) can inhibit frequencies of transient lower esophageal sphincter relaxation induced by gastric distention in cats].
Effects of 10.6-μm laser moxibustion and electroacupuncture at ST36 in a 5-Fu-induced diarrhea rat model.
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EA at PC6 Promotes Gastric Motility: Role of Brainstem Vagovagal Neurocircuits.针刺内关穴促进胃动力：脑干迷走神经神经回路的作用
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