• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

巴基斯坦南部空气中曲霉菌与哮喘加重的关联。

Association of airborne Aspergillus with asthma exacerbation in Southern Pakistan.

作者信息

Zubairi Ali Bin Sarwar, Azam Iqbal, Awan Safia, Zafar Afia, Imam Asif Ali

机构信息

Department of Medicine, Aga Khan University, Karachi 74800, Pakistan.

Department of Community Health Sciences, Aga Khan University, Karachi 74800, Pakistan.

出版信息

Asia Pac Allergy. 2014 Apr;4(2):91-8. doi: 10.5415/apallergy.2014.4.2.91. Epub 2014 Apr 29.

DOI:10.5415/apallergy.2014.4.2.91
PMID:24809014
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4005352/
Abstract

BACKGROUND

Exposure to airborne fungi has been related with exacerbation of asthma in adults and children leading to increased outpatient, emergency room visits, and hospitalizations. Hypersensitivity to these airborne fungi may be an important initial predisposing factor in the development and exacerbation of asthma.

OBJECTIVE

This study was conducted to determine an association between fungal types and spore concentrations with the risk of asthma exacerbation in adults.

METHODS

This cross-sectional study was conducted from May 2008 to August 2009 at the Aga Khan University Hospital Karachi, Pakistan. All adult (age≥16 years) patients presenting to the hospital with acute asthma exacerbation were enrolled after informed consent. A home survey was conducted for each patient to assess their environmental characteristics. Indoor air samples were also obtained from the patient's home to determine the type and spore concentration of fungi within the week of their enrollment in the study.

RESULTS

Three hundred and ninety-one patients with an acute asthma exacerbation were enrolled during the study period. The mean age of participants was 46 years (standard deviation, ±18 years) and 247 (63.2%) were females. A trend of higher asthma enrollment associated with higher Aspergillus concentrations was found in two consecutive summers. A total of nineteen types of fungi were found in air samples. Aspergillus spp. was the most frequently isolated fungus with acute asthma exacerbation.

CONCLUSION

An association of higher concentration of indoor Aspergillus spp. with asthma exacerbation in adults was observed in this study.

摘要

背景

接触空气中的真菌与成人和儿童哮喘加重有关，导致门诊、急诊就诊和住院人数增加。对这些空气中真菌的超敏反应可能是哮喘发生和加重的一个重要初始诱发因素。

目的

本研究旨在确定真菌类型和孢子浓度与成人哮喘加重风险之间的关联。

方法

本横断面研究于2008年5月至2009年8月在巴基斯坦卡拉奇的阿迦汗大学医院进行。所有因急性哮喘加重而到医院就诊的成年（年龄≥16岁）患者在获得知情同意后入组。对每位患者进行家庭调查以评估其环境特征。还从患者家中采集室内空气样本，以确定其入组研究当周室内真菌的类型和孢子浓度。

结果

研究期间共纳入391例急性哮喘加重患者。参与者的平均年龄为46岁（标准差，±18岁），女性有247例（63.2%）。在连续两个夏季发现哮喘入组率较高与曲霉浓度较高之间存在一种趋势。在空气样本中总共发现了19种真菌。曲霉属是急性哮喘加重时最常分离出的真菌。

结论

本研究观察到室内曲霉属浓度较高与成人哮喘加重之间存在关联。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8bf/4005352/2e76fd13c360/apa-4-91-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8bf/4005352/7cd52d5578aa/apa-4-91-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8bf/4005352/6dd810d90004/apa-4-91-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8bf/4005352/e2adca6fd8a7/apa-4-91-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8bf/4005352/2e76fd13c360/apa-4-91-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8bf/4005352/7cd52d5578aa/apa-4-91-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8bf/4005352/6dd810d90004/apa-4-91-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8bf/4005352/e2adca6fd8a7/apa-4-91-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8bf/4005352/2e76fd13c360/apa-4-91-g004.jpg

相似文献

1
Association of airborne Aspergillus with asthma exacerbation in Southern Pakistan.巴基斯坦南部空气中曲霉菌与哮喘加重的关联。
Asia Pac Allergy. 2014 Apr;4(2):91-8. doi: 10.5415/apallergy.2014.4.2.91. Epub 2014 Apr 29.
2
Relation of indoor and outdoor airborne fungal spore levels in the Kansas City metropolitan area.堪萨斯城都会区室内外空气传播真菌孢子水平的关系。
Allergy Asthma Proc. 2017 Mar 1;38(2):130-135. doi: 10.2500/aap.2017.38.4030.
3
Airborne and allergenic fungal spores of the Karachi environment and their correlation with meteorological factors.卡拉奇环境中的空气传播和致敏性真菌孢子及其与气象因素的相关性。
J Environ Monit. 2012 Mar;14(3):1006-13. doi: 10.1039/c2em10545d. Epub 2012 Feb 13.
4
Airborne fungi in the homes of children with asthma in low-income urban communities: The Inner-City Asthma Study.低收入城市社区哮喘儿童家中的空气传播真菌：内城哮喘研究
J Allergy Clin Immunol. 2004 Sep;114(3):599-606. doi: 10.1016/j.jaci.2004.05.064.
5
Indoor airborne fungal spores, house dampness and associations with environmental factors and respiratory health in children.室内空气传播的真菌孢子、房屋潮湿及其与环境因素和儿童呼吸健康的关联
Clin Exp Allergy. 1998 Apr;28(4):459-67. doi: 10.1046/j.1365-2222.1998.00255.x.
6
Indoor fungal diversity and asthma: a meta-analysis and systematic review of risk factors.室内真菌多样性与哮喘：风险因素的荟萃分析和系统评价。
J Allergy Clin Immunol. 2015 Jan;135(1):110-22. doi: 10.1016/j.jaci.2014.07.002. Epub 2014 Aug 23.
7
[Airborne fungal community composition in indoor environments in Beijing].[北京室内环境中的空气传播真菌群落组成]
Huan Jing Ke Xue. 2013 May;34(5):2031-7.
8
Isolation of Aspergillus fumigatus from sputum is associated with elevated airborne levels in homes of patients with asthma.从痰中分离出烟曲霉与哮喘患者家中空气中水平升高有关。
Indoor Air. 2013 Aug;23(4):275-84. doi: 10.1111/ina.12020. Epub 2013 Jan 25.
9
Indoor fungal concentration in the homes of allergic/asthmatic children in Delhi, India.印度德里过敏/哮喘儿童家中的室内真菌浓度。
Allergy Rhinol (Providence). 2011 Jan;2(1):21-32. doi: 10.2500/ar.2011.2.0005.
10
The characteristics of indoor and outdoor fungi and their relation with allergic respiratory diseases in the southern region of Turkey.土耳其南部地区室内外真菌的特征及其与过敏性呼吸道疾病的关系。
Environ Monit Assess. 2016 Jun;188(6):380. doi: 10.1007/s10661-016-5371-7. Epub 2016 May 28.

引用本文的文献

1
Impact of Fungal Spores on Asthma Prevalence and Hospitalization.真菌孢子对哮喘患病率和住院率的影响。
Int J Mol Sci. 2022 Apr 13;23(8):4313. doi: 10.3390/ijms23084313.
2
Indoor Microbial Exposures and Chronic Lung Disease: From Microbial Toxins to the Microbiome.室内微生物暴露与慢性肺病：从微生物毒素到微生物群落
Clin Chest Med. 2020 Dec;41(4):777-796. doi: 10.1016/j.ccm.2020.08.005.
3
and -Specific IgG Cut-Offs for the Diagnosis of Chronic Pulmonary Aspergillosis in Pakistan.巴基斯坦慢性肺曲霉病诊断的抗曲霉特异性IgG临界值

本文引用的文献

1
Associations between quantitative measures of fungi in home floor dust and lung function among older adults with chronic respiratory disease: a pilot study.慢性呼吸道疾病老年患者家中地板灰尘中真菌定量指标与肺功能的关联：一项试点研究。
J Asthma. 2012 Jun;49(5):502-9. doi: 10.3109/02770903.2012.682633.
2
Fungi and allergic lower respiratory tract diseases.真菌与过敏性下呼吸道疾病。
J Allergy Clin Immunol. 2012 Feb;129(2):280-91; quiz 292-3. doi: 10.1016/j.jaci.2011.12.970.
3
Respiratory and allergic health effects of dampness, mold, and dampness-related agents: a review of the epidemiologic evidence.
J Fungi (Basel). 2020 Oct 26;6(4):249. doi: 10.3390/jof6040249.
4
Identification of saprophytic and allergenic fungi in indoor and outdoor environments.室内外环境中腐生真菌和致敏真菌的鉴定。
Environ Monit Assess. 2018 Sep 6;190(10):574. doi: 10.1007/s10661-018-6952-4.
5
species in indoor environments and their possible occupational and public health hazards.室内环境中的物种及其可能的职业和公共卫生危害。
Curr Med Mycol. 2016 Mar;2(1):36-42. doi: 10.18869/acadpub.cmm.2.1.36.
6
Serious fungal infections in Pakistan.巴基斯坦的严重真菌感染。
Eur J Clin Microbiol Infect Dis. 2017 Jun;36(6):949-956. doi: 10.1007/s10096-017-2919-6. Epub 2017 Feb 4.
7
The characteristics of indoor and outdoor fungi and their relation with allergic respiratory diseases in the southern region of Turkey.土耳其南部地区室内外真菌的特征及其与过敏性呼吸道疾病的关系。
Environ Monit Assess. 2016 Jun;188(6):380. doi: 10.1007/s10661-016-5371-7. Epub 2016 May 28.
8
Immune responses to airborne fungi and non-invasive airway diseases.空气中真菌与非侵袭性气道疾病的免疫反应
Semin Immunopathol. 2015 Mar;37(2):83-96. doi: 10.1007/s00281-014-0471-3. Epub 2014 Dec 13.
潮湿、霉菌和潮湿相关因素对呼吸和过敏健康的影响：流行病学证据综述。
Environ Health Perspect. 2011 Jun;119(6):748-56. doi: 10.1289/ehp.1002410. Epub 2011 Jan 26.
4
Severe asthma and fungi: current evidence.严重哮喘与真菌：现有证据。
Med Mycol. 2011 Apr;49 Suppl 1:S150-7. doi: 10.3109/13693786.2010.504752. Epub 2010 Jul 22.
5
The similarities and differences of epidemic cycles of chronic obstructive pulmonary disease and asthma exacerbations.慢性阻塞性肺疾病和哮喘急性加重流行周期的异同。
Proc Am Thorac Soc. 2007 Dec;4(8):591-6. doi: 10.1513/pats.200706-064TH.
6
Meta-analyses of the associations of respiratory health effects with dampness and mold in homes.家庭中潮湿与霉菌对呼吸健康影响的关联的荟萃分析。
Indoor Air. 2007 Aug;17(4):284-96. doi: 10.1111/j.1600-0668.2007.00475.x.
7
Epidemic asthma and the role of the fungal mold Alternaria alternata.流行性哮喘与链格孢真菌的作用
J Allergy Clin Immunol. 2007 Sep;120(3):610-7. doi: 10.1016/j.jaci.2007.04.045. Epub 2007 Jul 10.
8
Exposure to Alternaria alternata in US homes is associated with asthma symptoms.在美国住宅中接触链格孢与哮喘症状有关。
J Allergy Clin Immunol. 2006 Oct;118(4):892-8. doi: 10.1016/j.jaci.2006.07.037.
9
Asthma exacerbations. 2: aetiology.哮喘加重。2：病因学。
Thorax. 2006 Sep;61(9):809-16. doi: 10.1136/thx.2005.045179.
10
Temporal associations between daily counts of fungal spores and asthma exacerbations.真菌孢子每日计数与哮喘急性加重之间的时间关联。
Occup Environ Med. 2006 Sep;63(9):580-90. doi: 10.1136/oem.2005.024448. Epub 2006 Mar 21.