Journeay W Shane, Goldman Rose H
Department of Medicine, Division of Physical Medicine and Rehabilitation, University of Toronto, Toronto, Ontario, Canada.
Am J Ind Med. 2014 Sep;57(9):1073-6. doi: 10.1002/ajim.22344. Epub 2014 May 8.
A 26-year-old female chemist formulated polymers and coatings usually using silver ink particles. When she later began working with nickel nanoparticle powder weighed out and handled on a lab bench with no protective measures, she developed throat irritation, nasal congestion, "post nasal drip," facial flushing, and new skin reactions to her earrings and belt buckle which were temporally related to working with the nanoparticles. Subsequently she was found to have a positive reaction to nickel on the T.R.U.E. patch test, and a normal range FEV1 that increased by 16% post bronchodilator. It was difficult returning her to work even in other parts of the building due to recurrence of symptoms. This incident triggered the company to make plans for better control measures for working with nickel nanoparticles. In conclusion, a worker developed nickel sensitization when working with nanoparticle nickel powder in a setting without any special respiratory protection or control measures.
一名26岁的女化学家通常使用银墨颗粒配制聚合物和涂料。后来，当她开始在实验室工作台上称量和处理镍纳米颗粒粉末且没有采取任何防护措施时，她出现了喉咙刺激、鼻塞、“鼻后滴漏”、面部潮红，以及对耳环和皮带扣出现新的皮肤反应，这些症状在时间上与接触纳米颗粒有关。随后，她在TRUE斑贴试验中对镍呈阳性反应，第一秒用力呼气量（FEV1）在正常范围内，使用支气管扩张剂后增加了16%。由于症状复发，即使让她在大楼的其他区域工作也很困难。这一事件促使公司制定了更好的镍纳米颗粒作业控制措施。总之，一名工人在没有任何特殊呼吸防护或控制措施的情况下处理纳米颗粒镍粉时发生了镍致敏。
