Guo Yongfang, Xing Mingqing, Sun Wenjuan, Yuan Xiaoyan, Dai Hongyan, Ding Huamin
Department of Cardiology, The Affiliated Hospital of Medical College Qingdao University, Qingdao, China.
Department of Cardiology, Qingdao Municipal Hospital, Qingdao, China.
Acupunct Med. 2014 Aug;32(4):313-7. doi: 10.1136/acupmed-2014-010530. Epub 2014 May 9.
Nesfatin-1 is an anorexigenic hormone suggested to regulate obesity.
To investigate the relationship between nesfatin-1 level and anthropometric and metabolic parameters in obese patients, and examine the change in plasma nesfatin-1 level after acupuncture treatment.
64 obese adult patients without diabetes and 58 normal weight control subjects were enrolled in this study. The obese patients were randomly divided into an acupuncture plus diet group (n=32) and a diet only group (n=32). Measurements were repeated after 45 days.
Body mass index (BMI), waist and hip circumferences, serum insulin, lipoprotein and insulin resistance measures were significantly higher, and plasma nesfatin-1 level was significantly lower, in obese patients than in normal weight controls. In addition, negative correlations were found between plasma nesfatin-1 level and BMI, waist and hip circumferences. Weight reduction in participants after acupuncture and diet restriction was 7.0% and 4.3%, respectively. Plasma nesfatin-1 level increased from 2.75±1.16 to 3.44±1.28 ng/mL and from 2.86±1.07 to 3.23±1.06 ng/mL in acupuncture and diet groups, respectively; the difference was significant, p<0.05.
Plasma nesfatin-1 level is reduced in obese adults, and is increased after acupuncture. The beneficial effect of acupuncture on obesity is associated with increased plasma nesfatin-1 level.
Nesfatin-1是一种被认为可调节肥胖的厌食激素。
研究肥胖患者中Nesfatin-1水平与人体测量学和代谢参数之间的关系，并检测针刺治疗后血浆Nesfatin-1水平的变化。
本研究纳入64例无糖尿病的肥胖成年患者和58例体重正常的对照者。肥胖患者被随机分为针刺加饮食组（n = 32）和单纯饮食组（n = 32）。45天后重复测量。
肥胖患者的体重指数（BMI）、腰围和臀围、血清胰岛素、脂蛋白及胰岛素抵抗指标均显著高于体重正常的对照者，而血浆Nesfatin-1水平显著低于对照者。此外，血浆Nesfatin-1水平与BMI、腰围和臀围呈负相关。针刺和饮食限制后参与者的体重减轻分别为7.0%和4.3%。针刺组和饮食组的血浆Nesfatin-1水平分别从2.75±1.16 ng/mL升高至3.44±1.28 ng/mL和从2.86±1.07 ng/mL升高至3.23±1.06 ng/mL；差异有统计学意义，p<0.05。
肥胖成年人血浆Nesfatin-1水平降低，针刺后升高。针刺对肥胖的有益作用与血浆Nesfatin-1水平升高有关。
