Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, College of Physicians and Surgeons, Columbia University, New York, NY.
Am J Obstet Gynecol. 2014 Nov;211(5):487.e1-6. doi: 10.1016/j.ajog.2014.05.009. Epub 2014 May 9.
To determine the effect of cinnamon on menstrual cyclicity and metabolic dysfunction in women with polycystic ovary syndrome (PCOS).
In a prospective, placebo controlled, double-blinded randomized trial, 45 women with PCOS were randomized (1:1) to receive cinnamon supplements (1.5 g/d) or placebo for 6 months. Menstrual cyclicity (average cycles/month) during the 6 months study period was compared between the 2 groups using the Mann-Whitney U test. Changes in menstrual cyclicity and insulin resistance between baseline and the 6 month study period were compared between the 2 groups using Wilcoxon signed rank tests.
The 45 women were randomized, 26 women completed 3 months of the study, and 17 women completed the entire 6 months of the study. During the 6 month intervention, menstrual cycles were more frequent in patients taking cinnamon compared with patients taking placebo (median, 0.75; interquartile range, 0.5-0.83 vs median, 0.25; interquartile range, 0-0.54; P = .0085; Mann Whitney U). In patients taking cinnamon, menstrual cyclicity improved from baseline (+ 0.23 cycles/month 95% confidence interval, 0.099-0.36), yet did not improve for women taking placebo. (P = .0076, Wilcoxon signed rank). Samples (n = 5) of serum from the luteal phase in different patients within the cinnamon group were thawed and ovulatory progesterone levels (>3 ng/mL) confirmed. Luteal phase progesterone levels (>3 ng/mL, n = 5) confirmed ovulatory menses. Measures of insulin resistance or serum androgen levels did not change for either group.
These preliminary data suggest that cinnamon supplementation improves menstrual cyclicity and may be an effective treatment option for some women with PCOS.
评估肉桂对多囊卵巢综合征（PCOS）女性月经周期和代谢功能障碍的影响。
这是一项前瞻性、安慰剂对照、双盲随机临床试验，45 名 PCOS 患者被随机（1:1）分为肉桂补充剂（1.5g/d）组或安慰剂组，分别接受 6 个月的治疗。使用 Mann-Whitney U 检验比较两组患者在 6 个月研究期间的月经周期（平均周期/月）。使用 Wilcoxon 符号秩检验比较两组患者在基线和 6 个月研究期间的月经周期和胰岛素抵抗变化。
45 名女性被随机分配，26 名女性完成了 3 个月的研究，17 名女性完成了整个 6 个月的研究。在 6 个月的干预期间，服用肉桂的患者月经周期比服用安慰剂的患者更频繁（中位数，0.75；四分位距，0.5-0.83 与中位数，0.25；四分位距，0-0.54；P =.0085；Mann-Whitney U）。服用肉桂的患者月经周期从基线开始改善（+0.23 个周期/月，95%置信区间，0.099-0.36），而服用安慰剂的患者则没有改善（P =.0076，Wilcoxon 符号秩）。肉桂组中不同患者的黄体期样本（n = 5）解冻，确认排卵后孕激素水平（>3ng/mL）。黄体期孕激素水平（>3ng/mL，n = 5）证实排卵性月经。两组患者的胰岛素抵抗或血清雄激素水平均未发生变化。
这些初步数据表明，肉桂补充剂可改善月经周期，可能是治疗某些 PCOS 女性的有效选择。
