Borzoei Azam, Rafraf Maryam, Asghari-Jafarabadi Mohammad
Students' Research Committee, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
Nutrition Research Center, Department of Community Nutrition, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
Asia Pac J Clin Nutr. 2018;27(3):556-563. doi: 10.6133/apjcn.062017.13.
The objectives of this study were to investigate the effects of cinnamon supplementation on glycemic indices, serum lipids and adiponectin in patients with polycystic ovary syndrome (PCOS).
This double-blind randomized controlled clinical trial was conducted on 84 overweight or obese PCOS patients. Subjects in cinnamon (n=42) and placebo (n=42) groups were given 3 cinnamon capsules (each one contained 500 mg cinnamon) or placebo daily for 8 weeks. Fasting blood samples, anthropometric measurements and dietary intake data were collected at the baseline and at the end of the trial. Data were analyzed by independent t test, paired t test and analysis of covariance.
Cinnamon significantly decreased serum fasting blood glucose, insulin, homeostatic model assessment for insulin resistance, total cholesterol and low-density lipoprotein cholesterol and weight and increased high-density lipoprotein cholesterol compared with placebo (all p<0.05). Serum triglyceride and body mass index significantly decreased in the cinnamon group, in comparison with baseline values (p=0.001 and p=0.002, respectively). No significant changes were seen in serum adiponectin in either group.
Short term supplementation of cinnamon had some favourable effects on metabolic risk factors of women with PCOS and may be useful in management of PCOS complications.
本研究旨在探讨补充肉桂对多囊卵巢综合征（PCOS）患者血糖指标、血脂和脂联素的影响。
本双盲随机对照临床试验对84例超重或肥胖的PCOS患者进行。肉桂组（n = 42）和安慰剂组（n = 42）的受试者分别每日服用3粒肉桂胶囊（每粒含500毫克肉桂）或安慰剂，持续8周。在基线期和试验结束时采集空腹血样、人体测量数据和饮食摄入数据。数据采用独立t检验、配对t检验和协方差分析进行分析。
与安慰剂相比，肉桂显著降低了血清空腹血糖、胰岛素、胰岛素抵抗稳态模型评估、总胆固醇和低密度脂蛋白胆固醇水平，减轻了体重，并提高了高密度脂蛋白胆固醇水平（所有p < 0.05）。与基线值相比，肉桂组的血清甘油三酯和体重指数显著降低（分别为p = 0.001和p = 0.002）。两组的血清脂联素均无显著变化。
短期补充肉桂对PCOS女性的代谢危险因素有一些有益影响，可能有助于PCOS并发症的管理。
