Chou Ruey-Hwang, Lu Cheng-You, Fan Jia-Rong, Yu Yung-Luen, Shyu Woei-Cherng
Graduate Institute of Cancer Biology, Center for Molecular Medicine, China Medical University, Taichung, Taiwan.
Cell Transplant. 2014;23(4-5):567-71. doi: 10.3727/096368914X678508.
Olfactory ensheathing cells (OECs) are unique glia cells restricted to the primary olfactory system including the olfactory mucosa, olfactory nerve, and the outer nerve layer of the olfactory bulb. OECs guide growing olfactory axons from the neurons of the nasal cavity olfactory mucosa to the olfactory bulb to connect both the peripheral nervous system (PNS) and central nervous system (CNS). Based on these specialized abilities of OECs, transplantation of OECs to injury sites has been widely investigated for their potential therapeutic applications in neural repair in different injuries. In this article, we reviewed the properties of OECs and their roles in olfactory regeneration and in treatment of different injuries including spinal cord injury, PNS injury, and stroke and neurodegenerative diseases.
嗅鞘细胞（OECs）是一种独特的神经胶质细胞，仅存在于包括嗅黏膜、嗅神经和嗅球外神经层在内的初级嗅觉系统中。嗅鞘细胞引导生长中的嗅觉轴突从鼻腔嗅黏膜的神经元到达嗅球，从而连接外周神经系统（PNS）和中枢神经系统（CNS）。基于嗅鞘细胞的这些特殊能力，将嗅鞘细胞移植到损伤部位已被广泛研究，以探索其在不同损伤的神经修复中的潜在治疗应用。在本文中，我们综述了嗅鞘细胞的特性及其在嗅觉再生以及治疗包括脊髓损伤、外周神经系统损伤、中风和神经退行性疾病在内的不同损伤中的作用。
