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谷物种子中的月见草素:其来源是什么?

Lunasin in cereal seeds: What is the origin?

作者信息

Mitchell Rowan A C, Lovegrove Alison, Shewry Peter R

机构信息

Department of Plant Biology and Crop Science, Rothamsted Research, Harpenden, Hertfordshire AL5 2JQ, UK.

Department of Plant Biology and Crop Science, Rothamsted Research, Harpenden, Hertfordshire AL5 2JQ, UK ; School of Agriculture, Policy and Development, University of Reading, Earley Gate, Whiteknights Road, Reading RG6 6AR, UK.

出版信息

J Cereal Sci. 2013 May;57(3):267-269. doi: 10.1016/j.jcs.2013.01.013.

DOI:10.1016/j.jcs.2013.01.013
PMID:24817784
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4010285/
Abstract

Lunasin is a peptide from soybean seeds which has been demonstrated to have anticancer properties. It has also been reported in cereal seeds: wheat, rye, barley and Triticale. However, extensive searches of transcriptome and DNA sequence databases for wheat and other cereals have failed to identify sequences encoding either the lunasin peptide or a precursor protein. This raises the question of the origin of the lunasin reported in cereal grain.

摘要

芦那辛是一种来自大豆种子的肽,已被证明具有抗癌特性。在谷类种子中也有相关报道,如小麦、黑麦、大麦和小黑麦。然而,对小麦和其他谷类的转录组和DNA序列数据库进行广泛搜索,未能鉴定出编码芦那辛肽或前体蛋白的序列。这就引发了关于谷类中报道的芦那辛起源的问题。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/120b/4010285/9c88d3959048/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/120b/4010285/c016cd39c746/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/120b/4010285/9c88d3959048/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/120b/4010285/c016cd39c746/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/120b/4010285/9c88d3959048/gr2.jpg

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引用本文的文献

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3
The soybean-derived peptide lunasin inhibits non-small cell lung cancer cell proliferation by suppressing phosphorylation of the retinoblastoma protein.

本文引用的文献

1
A physical, genetic and functional sequence assembly of the barley genome.大麦基因组的物理、遗传和功能序列组装。
Nature. 2012 Nov 29;491(7426):711-6. doi: 10.1038/nature11543. Epub 2012 Oct 17.
2
Cell walls of developing wheat starchy endosperm: comparison of composition and RNA-Seq transcriptome.发育中小麦粉质胚乳细胞壁的组成和 RNA-Seq 转录组比较。
Plant Physiol. 2012 Feb;158(2):612-27. doi: 10.1104/pp.111.189191. Epub 2011 Nov 28.
3
Synthesis of the cancer preventive peptide lunasin by lactic acid bacteria during sourdough fermentation.
源自大豆的肽lunasin通过抑制视网膜母细胞瘤蛋白的磷酸化来抑制非小细胞肺癌细胞的增殖。
Oncotarget. 2015 Mar 10;6(7):4649-62. doi: 10.18632/oncotarget.3080.
利用乳酸菌在酸面团发酵过程中合成抑癌肽 lunasin。
Nutr Cancer. 2012;64(1):111-20. doi: 10.1080/01635581.2012.630159. Epub 2011 Nov 18.
4
Lunasin is prevalent in barley and is bioavailable and bioactive in in vivo and in vitro studies.Lunasin 普遍存在于大麦中,并且在体内和体外研究中具有生物利用度和生物活性。
Nutr Cancer. 2010;62(8):1113-9. doi: 10.1080/01635581.2010.515529.
5
Amaranth lunasin-like peptide internalizes into the cell nucleus and inhibits chemical carcinogen-induced transformation of NIH-3T3 cells.苋菜凝朊氨酸样肽可内化进入细胞核,并抑制化学致癌物诱导的 NIH-3T3 细胞转化。
Peptides. 2010 Sep;31(9):1635-42. doi: 10.1016/j.peptides.2010.06.014. Epub 2010 Jun 25.
6
The cancer preventive seed peptide lunasin from rye is bioavailable and bioactive.黑麦中具有防癌作用的种子活性肽 lunasin 可被人体吸收且具有生物活性。
Nutr Cancer. 2009;61(5):680-6. doi: 10.1080/01635580902850082.
7
Lunasin, a novel seed peptide for cancer prevention.芦那辛,一种用于癌症预防的新型种子肽。
Peptides. 2009 Feb;30(2):426-30. doi: 10.1016/j.peptides.2008.11.002. Epub 2008 Nov 13.
8
Bioactive peptides in amaranth (Amaranthus hypochondriacus) seed.苋属(皱果苋)种子中的生物活性肽。
J Agric Food Chem. 2008 Feb 27;56(4):1233-40. doi: 10.1021/jf072911z. Epub 2008 Jan 23.
9
Cancer-preventive peptide lunasin from Solanum nigrum L. inhibits acetylation of core histones H3 and H4 and phosphorylation of retinoblastoma protein (Rb).来自龙葵的具有癌症预防作用的肽lunasin可抑制核心组蛋白H3和H4的乙酰化以及视网膜母细胞瘤蛋白(Rb)的磷酸化。
J Agric Food Chem. 2007 Dec 26;55(26):10707-13. doi: 10.1021/jf072363p. Epub 2007 Nov 27.
10
The cancer preventive peptide lunasin from wheat inhibits core histone acetylation.来自小麦的具有癌症预防作用的肽lunasin可抑制核心组蛋白乙酰化。
Cancer Lett. 2007 Sep 18;255(1):42-8. doi: 10.1016/j.canlet.2007.03.022. Epub 2007 May 3.