McLeod Kevin R, Langevin Lisa Marie, Goodyear Bradley G, Dewey Deborah
Medical Science, University of Calgary, Calgary, Alberta, Canada ; Alberta Children's Hospital Research Institute for Child and Maternal Health, University of Calgary, Calgary, Alberta, Canada.
Department of Paediatrics, University of Calgary, Calgary, Alberta, Canada ; Alberta Children's Hospital Research Institute for Child and Maternal Health, University of Calgary, Calgary, Alberta, Canada ; Behavioural Research Unit, Alberta Children's Hospital, Calgary, Alberta, Canada.
Neuroimage Clin. 2014 Mar 26;4:566-75. doi: 10.1016/j.nicl.2014.03.010. eCollection 2014.
Developmental coordination disorder (DCD) and attention deficit/hyperactivity disorder (ADHD) are prevalent childhood disorders that frequently co-occur. Evidence from neuroimaging research suggests that children with these disorders exhibit disruptions in motor circuitry, which could account for the high rate of co-occurrence. The primary objective of this study was to investigate the functional connections of the motor network in children with DCD and/or ADHD compared to typically developing controls, with the aim of identifying common neurophysiological substrates. Resting-state fMRI was performed on seven children with DCD, 21 with ADHD, 18 with DCD + ADHD and 23 controls. Resting-state connectivity of the primary motor cortex was compared between each group and controls, using age as a co-factor. Relative to controls, children with DCD and/or ADHD exhibited similar reductions in functional connectivity between the primary motor cortex and the bilateral inferior frontal gyri, right supramarginal gyrus, angular gyri, insular cortices, amygdala, putamen, and pallidum. In addition, children with DCD and/or ADHD exhibited different age-related patterns of connectivity, compared to controls. These findings suggest that children with DCD and/or ADHD exhibit disruptions in motor circuitry, which may contribute to problems with motor functioning and attention. Our results support the existence of common neurophysiological substrates underlying both motor and attention problems.
发育性协调障碍（DCD）和注意缺陷多动障碍（ADHD）是常见的儿童期疾病，且经常同时出现。神经影像学研究的证据表明，患有这些疾病的儿童表现出运动神经回路的紊乱，这可能解释了它们的高共病率。本研究的主要目的是调查与发育正常的对照组相比，患有DCD和/或ADHD的儿童运动网络的功能连接，以确定共同的神经生理基础。对7名患有DCD的儿童、21名患有ADHD的儿童、18名患有DCD+ADHD的儿童和23名对照组儿童进行了静息态功能磁共振成像（fMRI）检查。以年龄作为协变量，比较了每组与对照组之间初级运动皮层的静息态连接性。相对于对照组，患有DCD和/或ADHD的儿童在初级运动皮层与双侧额下回、右侧缘上回、角回、岛叶皮质、杏仁核、壳核和苍白球之间的功能连接性有类似程度的降低。此外，与对照组相比，患有DCD和/或ADHD的儿童表现出与年龄相关的不同连接模式。这些发现表明，患有DCD和/或ADHD的儿童表现出运动神经回路的紊乱，这可能导致运动功能和注意力方面的问题。我们的结果支持运动和注意力问题存在共同的神经生理基础。
