Nakano R, Fujita N, Sato S, Inuzuka T, Sakimura K, Ishiguro H, Mishina M, Miyatake T
Department of Neurology, Niigata University, Japan.
Biochem Biophys Res Commun. 1991 Jul 15;178(1):282-90. doi: 10.1016/0006-291x(91)91811-p.
The mouse myelin-associated glycoprotein gene was isolated from a mouse gene library. This gene was split into 13 exons distributed about 15 kb in length. Each extracellular immunoglobulin-related domain was encoded by a single exon, and RNA splicing between those exons occurred between the first and second nucleotides of the junctional codon, the features of which are conserved in most of the genes of the immunoglobulin superfamily. The sequence of the 5'-flanking region appeared to have some regions homologous to other myelin proteins, which suggested that they were possible cis-elements for specific expression of oligodendrocytes.
从小鼠基因文库中分离出小鼠髓鞘相关糖蛋白基因。该基因被分成13个外显子，长度约为15 kb。每个细胞外免疫球蛋白相关结构域由单个外显子编码，这些外显子之间的RNA剪接发生在连接密码子的第一个和第二个核苷酸之间，其特征在免疫球蛋白超家族的大多数基因中是保守的。5'侧翼区的序列似乎有一些与其他髓鞘蛋白同源的区域，这表明它们可能是少突胶质细胞特异性表达的顺式元件。
