Departments of Dermatology, Venereology and Leprosy, Adichunchanagiri Institute of Medical Sciences, BG Nagara, Bellur, Karnataka, India.
Indian J Dermatol Venereol Leprol. 2014 May-Jun;80(3):243-6. doi: 10.4103/0378-6323.132252.
Giant congenital nevomelanocytic nevus (GCNN) is a rare variant of congenital melanocytic nevus measuring >20 cm in size that often has a garment-like distribution. Regular follow up is recommended because of a risk of melanoma transformation of 4.6%. We report a 14-year-old boy with gradual regression of giant congenital melanocytic nevus over the left upper limb, chest, back and axilla, whom we have followed-up since birth. At birth, a hyperpigmented jet-black patch without hair was present over the left side of torso and upper limb including palms and nails. Follow up at the ages of 1, 5, 11 and 14 years showed progressive spontaneous regression of the nevus resulting in shiny atrophic skin, diffuse hypopigmentation, lentigo-like macules, nodules and arthrogryphosis of affected areas. Histopathology of the lesions on follow-up revealed absence of pigmented nevus cells in the regressing areas and thickened sclerotic collagen bundles.
先天性巨大黑素细胞痣（GCNN）是一种罕见的先天性黑素细胞痣变体，大小>20cm，常呈衣状分布。由于有 4.6%的黑色素瘤恶变风险，建议定期随访。我们报告了一例 14 岁男孩，其左侧上肢、胸部、背部和腋窝的先天性巨大黑素细胞痣逐渐消退，我们自出生以来一直对其进行随访。出生时，左侧躯干和上肢（包括手掌和指甲）有一块色素沉着的乌黑斑块，无毛发。1 岁、5 岁、11 岁和 14 岁的随访显示，痣的自发消退逐渐进展，导致受累区域出现有光泽的萎缩性皮肤、弥漫性色素减退、雀斑样斑、结节和关节强硬。随访时病变的组织病理学显示，消退区域内无色素性黑素细胞痣细胞，增厚的硬化胶原束。
