Department of Chemistry and Biochemistry, Skaggs School of Pharmacy and Pharmaceutical Science, University of California, San Diego, La Jolla, 92093, USA.
Angew Chem Int Ed Engl. 2012 May 14;51(20):4877-81. doi: 10.1002/anie.201108119. Epub 2012 Apr 4.
Game-SET-match: Pyrrole aminoimidazole alkaloids (PAIs) are metabiosynthesized from chlorinated analogues of oroidin by cell-free enzyme preparations from PAI-producing sponges. Evidence and implications for the biosynthesis of PAIs include putative single-electron transfers (SETs) that promote C-C bond-forming reactions of precursors.
局-胜-赛定:吡咯并咪唑生物碱(PAIs)是由产 PAI 海绵的无细胞酶制剂,从类胡萝卜素的氯化类似物代谢合成而来。PAIs 生物合成的证据和意义包括推测的单电子转移(SET),促进了前体的 C-C 键形成反应。