Gardner G, Mesler D, Gitelman H J
School of Medicine, University of North Carolina, Chapel Hill.
Ren Fail. 1989;11(2-3):133-7. doi: 10.3109/08860228909066955.
This report describes a patient who developed the hemolytic uremic syndrome while undergoing chemotherapy with cisplatin, bleomycin, and vincristine, for metastatic squamous cell cancer of the floor of the mouth. In spite of dialysis and plasmapheresis, the patient died. This complication has rarely been reported in association with cisplatin, bleomycin, or vincristine therapy. The etiology of this syndrome is uncertain but may be related to scleroderma-like endothelial injury and vasospasm caused by bleomycin combination chemotherapy. It is notable that the development of the hemolytic uremic syndrome in conjunction with this combination of agents has been fatal in all patients over the age of 50 with squamous cell cancers.
本报告描述了一名患者，该患者在接受顺铂、博来霉素和长春新碱化疗以治疗口腔底部转移性鳞状细胞癌时发生了溶血性尿毒症综合征。尽管进行了透析和血浆置换，患者仍死亡。这种并发症很少与顺铂、博来霉素或长春新碱治疗相关的报道。该综合征的病因尚不确定，但可能与博来霉素联合化疗引起的硬皮病样内皮损伤和血管痉挛有关。值得注意的是，对于所有50岁以上患有鳞状细胞癌的患者，这种药物组合引发溶血性尿毒症综合征一直是致命的。
