Watson P R, Guthrie T H, Caruana R J
Medical College of Georgia, Augusta 30912.
Cancer. 1989 Oct 1;64(7):1400-3. doi: 10.1002/1097-0142(19891001)64:7<1400::aid-cncr2820640705>3.0.co;2-n.
Cisplatin-associated hemolytic-uremic syndrome (HUS), an under-reported form of HUS induced by chemotherapy, typically pursues a fulminant and lethal course. We report the cases of two patients with squamous cell carcinoma of the head and neck who developed massive hemolysis, profound thrombocytopenia, and dialysis-dependent renal failure after therapy with cisplatin. Plasma exchange was ineffective in both patients, but plasma perfusion with a staphylococcal protein A column produced a dramatic and permanent response in the second patient. These cases show the importance of considering HUS as a cause of renal failure in such patients who receive cisplatin-based chemotherapy, and support the role of staphylococcal protein A plasma perfusion as treatment for this condition.
顺铂相关溶血尿毒综合征（HUS）是化疗诱发的一种报道较少的HUS形式，通常病情凶险且致命。我们报告了2例头颈部鳞状细胞癌患者，他们在接受顺铂治疗后出现大量溶血、严重血小板减少和依赖透析的肾衰竭。血浆置换对这2例患者均无效，但用葡萄球菌蛋白A柱进行血浆灌注使第2例患者产生了显著且持久的反应。这些病例表明，对于接受基于顺铂化疗的此类患者，应考虑HUS作为肾衰竭病因的重要性，并支持葡萄球菌蛋白A血浆灌注作为该病治疗手段的作用。
