多发性硬化症的视神经乳头和旁黄斑区光学相干断层扫描血管造影。
Optical coherence tomography angiography of optic nerve head and parafovea in multiple sclerosis.
机构信息
Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, USA Affiliated Sixth People's Hospital Shanghai Jiao Tong University, Shanghai, P.R. China.
Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, USA.
出版信息
Br J Ophthalmol. 2014 Oct;98(10):1368-73. doi: 10.1136/bjophthalmol-2013-304547. Epub 2014 May 15.
AIMS
To investigate swept-source optical coherence tomography (OCT) angiography in the optic nerve head (ONH) and parafoveal regions in patients with multiple sclerosis (MS).
METHODS
Fifty-two MS eyes and 21 healthy control (HC) eyes were included. There were two MS subgroups: 38 MS eyes without an optic neuritis (ON) history (MS -ON), and 14 MS eyes with an ON history (MS +ON). The OCT images were captured by high-speed 1050 nm swept-source OCT. The ONH flow index (FI) and parafoveal FI were quantified from OCT angiograms.
RESULTS
The mean ONH FI was 0.160 ± 0.010 for the HC group, 0.156 ± 0.017 for the MS-ON group, and 0.140 ± 0.020 for the MS+ON group. The ONH FI of the MS+ON group was reduced by 12.5% compared to HC eyes (p=0.004). A higher percentage of MS+ON eyes had abnormal ONH FI compared to HC patients (43% vs 5%, p=0.01). Mean parafoveal FIs were 0.126 ± 0.007, 0.127 ± 0.010, and 0.129 ± 0.005 for the HC, MS-ON, and MS +ON groups, respectively, and did not differ significantly among them. The coefficient of variation (CV) of intravisit repeatability and intervisit reproducibility were 1.03% and 4.53% for ONH FI, and 1.65% and 3.55% for parafoveal FI.
CONCLUSIONS
Based on OCT angiography, the FI measurement is feasible, highly repeatable and reproducible, and it is suitable for clinical measurement of ONH and parafoveal perfusion. The ONH FI may be useful in detecting damage from ON and quantifying its severity.
目的
探讨多发性硬化症（MS）患者视神经头（ONH）和旁黄斑区的扫频光学相干断层扫描（OCT）血管造影。
方法
纳入 52 只 MS 眼和 21 只健康对照组（HC）眼。MS 组有两个亚组：38 只无视神经炎（ON）病史的 MS 眼（MS-ON）和 14 只有 ON 病史的 MS 眼（MS+ON）。OCT 图像由高速 1050nm 扫频 OCT 采集。从 OCT 血管造影中定量计算 ONH 血流指数（FI）和旁黄斑区 FI。
结果
HC 组的平均 ONH FI 为 0.160 ± 0.010，MS-ON 组为 0.156 ± 0.017，MS+ON 组为 0.140 ± 0.020。MS+ON 组的 ONH FI 比 HC 眼减少了 12.5%（p=0.004）。与 HC 患者相比，更多的 MS+ON 眼的 ONH FI 异常（43%比 5%，p=0.01）。HC 组、MS-ON 组和 MS+ON 组的平均旁黄斑区 FI 分别为 0.126 ± 0.007、0.127 ± 0.010 和 0.129 ± 0.005，差异无统计学意义。ONH FI 的日内重复性和日间可重复性的变异系数（CV）分别为 1.03%和 4.53%，旁黄斑区 FI 分别为 1.65%和 3.55%。
结论
基于 OCT 血管造影，FI 测量是可行的，具有高度的可重复性和可再现性，适用于 ONH 和旁黄斑区灌注的临床测量。ONH FI 可能有助于检测 ON 损伤并量化其严重程度。
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