Choi Youngju, Akazawa Nobuhiko, Zempo-Miyaki Asako, Ra Song-Gyu, Shiraki Hitoshi, Ajisaka Ryuichi, Maeda Seiji
1Department of Sports Medicine, Faculty of Health and Sport Sciences, University of Tsukuba, Ibaraki, Japan; 2Faculty of Medicine, University of Tsukuba, Ibaraki, Japan; and 3Division of Sports Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan.
J Strength Cond Res. 2016 Aug;30(8):2279-85. doi: 10.1519/JSC.0000000000000536.
Choi, Y, Akazawa, N, Zempo-Miyaki, A, Ra, S-G, Shiraki, H, Ajisaka, R, and Maeda, S. Acute effect of high-intensity eccentric exercise on vascular endothelial function in young men. J Strength Cond Res 30(8): 2279-2285, 2016-Increased central arterial stiffness is as an independent risk factor for cardiovascular disease. Evidence regarding the effects of high-intensity resistance exercise on vascular endothelial function and central arterial stiffness is conflicting. The purpose of this study was to examine the effects of acute high-intensity eccentric exercise on vascular endothelial function and central arterial stiffness. We evaluated the acute changes in endothelium-dependent flow-mediated dilation (FMD), low-flow-mediated constriction (L-FMC), and arterial stiffness after high-intensity eccentric exercise. Seven healthy, sedentary men (age, 24 ± 1 year) performed maximal eccentric elbow flexor exercise using their nondominant arm. Before and 45 minutes after eccentric exercise, carotid arterial compliance and brachial artery FMD and L-FMC in the nonexercised arm were measured. Carotid arterial compliance was significantly decreased, and β-stiffness index significantly increased after eccentric exercise. Brachial FMD was significantly reduced after eccentric exercise, whereas there was no significant difference in brachial L-FMC before and after eccentric exercise. A positive correlation was detected between change in arterial compliance and change in FMD (r = 0.779; p ≤ 0.05), and a negative correlation was detected between change in β-stiffness index and change in FMD (r = -0.891; p < 0.01) with eccentric exercise. In this study, acute high-intensity eccentric exercise increased central arterial stiffness; this increase was accompanied by a decrease in endothelial function caused by reduced endothelium-dependent vasodilation but not by a change in endothelium-dependent vasoconstriction.
崔，Y，赤泽，N，曾保宫城，A，罗，S - G，白木，H，安坂，R，以及前田，S。高强度离心运动对年轻男性血管内皮功能的急性影响。《力量与体能研究杂志》30(8): 2279 - 2285，2016年——中心动脉僵硬度增加是心血管疾病的独立危险因素。关于高强度抗阻运动对血管内皮功能和中心动脉僵硬度影响的证据相互矛盾。本研究的目的是检验急性高强度离心运动对血管内皮功能和中心动脉僵硬度的影响。我们评估了高强度离心运动后内皮依赖性血流介导的血管舒张（FMD）、低流量介导的血管收缩（L - FMC）和动脉僵硬度的急性变化。七名健康的久坐男性（年龄，24±1岁）用非优势手臂进行了最大强度的离心性肘屈肌运动。在离心运动前和运动后45分钟，测量了未运动手臂的颈动脉顺应性以及肱动脉FMD和L - FMC。离心运动后颈动脉顺应性显著降低，β僵硬度指数显著升高。离心运动后肱动脉FMD显著降低，而离心运动前后肱动脉L - FMC无显著差异。在离心运动中，检测到动脉顺应性变化与FMD变化之间存在正相关（r = 0.779；p≤0.05），β僵硬度指数变化与FMD变化之间存在负相关（r = - 0.891；p < 0.01）。在本研究中，急性高强度离心运动增加了中心动脉僵硬度；这种增加伴随着内皮依赖性血管舒张减少导致的内皮功能下降，但不是由内皮依赖性血管收缩的变化引起的。
