Faculty of Sports and Health Science, Fukuoka University, Fukuoka, Japan.
Faculty of Health and Sport Sciences, University of Tsukuba, Tsukuba, Japan.
Adv Exp Med Biol. 2019;1155:407-414. doi: 10.1007/978-981-13-8023-5_38.
High-intensity resistance exercise has been shown to increase arterial stiffness and reduce vascular endothelial function. Taurine supplementation has a favorable effect on maintaining vascular function. We had previously reported that taurine supplementation attenuated increases in resistance exercise-induced arterial stiffness. In the present study, we further investigate the effects of taurine supplementation on vascular endothelial function at rest and after resistance exercise.Twenty-nine healthy men were recruited and randomly assigned to either the placebo supplement group (n = 14) or the taurine supplement group (n = 15) in a double-blinded manner. Subjects were required to ingest 6 g of either a placebo or the taurine supplement for 2 weeks prior to and 3 days following the exercise. Two weeks after the commencement of supplementation, the subjects were asked to perform 2 sets of 20 repetitive unilateral maximal-effort resistance exercise of the elbow flexors on a Biodex isokinetic dynamometer, with each contraction lasting 3 s, with 1 repetition performed every 9 s and 4 min rest in between sets. We evaluated the changes in brachial artery flow-mediated dilation (FMD) in the non-exercised arm as an index of vascular endothelial function. Relative and absolute FMDs were measured prior to supplementation, before exercise, and 24, 48, and 96 h after exercise.Two weeks of taurine supplementation significantly increased both relative and absolute FMDs. Baseline diameter significantly increased at 96 h following the exercise in both groups. However, there was no change in the peak diameter. Consequently, both relative and absolute FMDs were significantly reduced at 96 h after the exercise in both groups. Taurine supplementation does not affect resistance exercise-induced reduction in FMD.Two weeks of taurine supplementation (6 g/day) significantly increased vascular endothelial function at rest; however, taurine supplementation did not improve resistance exercise-induced reduction in FMD.
高强度抗阻运动已被证明会增加动脉僵硬度并降低血管内皮功能。牛磺酸补充剂对维持血管功能有有利影响。我们之前曾报道过，牛磺酸补充剂可减轻抗阻运动引起的动脉僵硬度增加。在本研究中，我们进一步研究了牛磺酸补充剂对休息时和抗阻运动后血管内皮功能的影响。
我们招募了 29 名健康男性，并以双盲方式随机分为安慰剂补充组（n=14）或牛磺酸补充组（n=15）。受试者需要在运动前和运动后 3 天内每天摄入 6 克安慰剂或牛磺酸补充剂。补充开始后 2 周，要求受试者在 Biodex 等速测力计上进行 2 组 20 次单侧最大努力抗阻运动，每组收缩持续 3 秒，每 9 秒重复 1 次，每组之间休息 4 分钟。我们评估了非运动手臂肱动脉血流介导的扩张（FMD）的变化，作为血管内皮功能的指标。在补充前、运动前以及运动后 24、48 和 96 小时测量相对和绝对 FMD。
牛磺酸补充剂 2 周显著增加了相对和绝对 FMD。两组在运动后 96 小时时基底直径显著增加。然而，峰值直径没有变化。因此，两组在运动后 96 小时时相对和绝对 FMD 均显著降低。牛磺酸补充剂不影响抗阻运动引起的 FMD 降低。
牛磺酸补充剂（每天 6 克）2 周可显著增加休息时的血管内皮功能；然而，牛磺酸补充剂不能改善抗阻运动引起的 FMD 降低。
